Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade
Inducing immunogenic tumor cell death to stimulate the response to immune checkpoint blockade has not yet been effectively translated into clinical practice. We recently discovered that stressed/injured but still viable tumor cells are critical for T-cell priming and substantially improve responses...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Informa UK Limited
2023
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| Online Access: | https://hdl.handle.net/1721.1/147026 |
| _version_ | 1826204757207810048 |
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| author | Sriram, Ganapathy Emmons, Tiffany R Milling, Lauren E Irvine, Darrell J Yaffe, Michael B |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Sriram, Ganapathy Emmons, Tiffany R Milling, Lauren E Irvine, Darrell J Yaffe, Michael B |
| author_sort | Sriram, Ganapathy |
| collection | MIT |
| description | Inducing immunogenic tumor cell death to stimulate the response to immune checkpoint blockade has not yet been effectively translated into clinical practice. We recently discovered that stressed/injured but still viable tumor cells are critical for T-cell priming and substantially improve responses to systemic anti-PD1/CTLA4. Therapeutic tumor cell injury, rather than complete killing, in the tumor microenvironment may enhance efficacy of immunotherapy in various cancers. |
| first_indexed | 2024-09-23T13:00:36Z |
| format | Article |
| id | mit-1721.1/147026 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T13:00:36Z |
| publishDate | 2023 |
| publisher | Informa UK Limited |
| record_format | dspace |
| spelling | mit-1721.1/1470262023-01-10T03:23:55Z Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade Sriram, Ganapathy Emmons, Tiffany R Milling, Lauren E Irvine, Darrell J Yaffe, Michael B Massachusetts Institute of Technology. Department of Biology Inducing immunogenic tumor cell death to stimulate the response to immune checkpoint blockade has not yet been effectively translated into clinical practice. We recently discovered that stressed/injured but still viable tumor cells are critical for T-cell priming and substantially improve responses to systemic anti-PD1/CTLA4. Therapeutic tumor cell injury, rather than complete killing, in the tumor microenvironment may enhance efficacy of immunotherapy in various cancers. 2023-01-09T18:45:45Z 2023-01-09T18:45:45Z 2022 2023-01-09T18:32:52Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/147026 Sriram, Ganapathy, Emmons, Tiffany R, Milling, Lauren E, Irvine, Darrell J and Yaffe, Michael B. 2022. "Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade." Molecular & Cellular Oncology, 9 (1). en 10.1080/23723556.2022.2039038 Molecular & Cellular Oncology Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Informa UK Limited Taylor & Francis |
| spellingShingle | Sriram, Ganapathy Emmons, Tiffany R Milling, Lauren E Irvine, Darrell J Yaffe, Michael B Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade |
| title | Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade |
| title_full | Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade |
| title_fullStr | Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade |
| title_full_unstemmed | Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade |
| title_short | Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade |
| title_sort | immunogenic cell stress and injury versus immunogenic cell death implications for improving cancer treatment with immune checkpoint blockade |
| url | https://hdl.handle.net/1721.1/147026 |
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