Proteomics of Coagulopathy Following Injury Reveals Limitations of Using Laboratory Assessment to Define Trauma-Induced Coagulopathy to Predict Massive Transfusion

Proteomics of Coagulopathy Following Injury Reveals Limitations of Using Laboratory Assessment to Define Trauma-Induced Coagulopathy to Predict Massive Transfusion

OBJECTIVE: Trauma-induced coagulopathy (TIC) is provoked by multiple mechanisms and is perceived to be one driver of massive transfusions (MT). Single laboratory values using prothrombin time (INR) or thrombelastography (TEG) are used to clinically define this complex process. We used a proteomics a...

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Bibliographic Details
Main Authors: Moore, Hunter B, Neal, Matthew D, Bertolet, Marnie, Joughin, Brian A, Yaffe, Michael B, Barrett, Christopher D, Bird, Molly A, Tracy, Russell P, Moore, Ernest E, Sperry, Jason L, Zuckerbraun, Brian S, Park, Myung S, Cohen, Mitchell J, Wisniewski, Stephen R, Morrissey, James H
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Ovid Technologies (Wolters Kluwer Health) 2023
Online Access:https://hdl.handle.net/1721.1/147028

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