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1826205298623250432
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| author2 |
Massachusetts Institute of Technology. Department of Biology
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| author_facet |
Massachusetts Institute of Technology. Department of Biology
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| collection |
MIT
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| description |
White adipose tissue, once regarded as morphologically and functionally bland, is now recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of biological processes including energy homeostasis, glucose and lipid handling, blood pressure control and host defence1. High-fat feeding and other metabolic stressors cause marked changes in adipose morphology, physiology and cellular composition1, and alterations in adiposity are associated with insulin resistance, dyslipidemia and type 2 diabetes2. Here we provide detailed cellular atlases of human and mouse subcutaneous and visceral white fat at single-cell resolution across a range of body weight. We identify subpopulations of adipocytes, adipose stem and progenitor cells, vascular and immune cells and demonstrate commonalities and differences across species and dietary conditions. We link specific cell types to increased risk of metabolic disease and provide an initial blueprint for a comprehensive set of interactions between individual cell types in the adipose niche in leanness and obesity. These data comprise an extensive resource for the exploration of genes, traits and cell types in the function of white adipose tissue across species, depots and nutritional conditions.
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| first_indexed |
2024-09-23T13:10:28Z
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| format |
Article
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| id |
mit-1721.1/147064
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| institution |
Massachusetts Institute of Technology
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| language |
English
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| last_indexed |
2024-09-23T13:10:28Z
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| publishDate |
2023
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| publisher |
Springer Science and Business Media LLC
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| record_format |
dspace
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| spelling |
mit-1721.1/1470642023-01-12T03:22:55Z A single-cell atlas of human and mouse white adipose tissue Massachusetts Institute of Technology. Department of Biology White adipose tissue, once regarded as morphologically and functionally bland, is now recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of biological processes including energy homeostasis, glucose and lipid handling, blood pressure control and host defence1. High-fat feeding and other metabolic stressors cause marked changes in adipose morphology, physiology and cellular composition1, and alterations in adiposity are associated with insulin resistance, dyslipidemia and type 2 diabetes2. Here we provide detailed cellular atlases of human and mouse subcutaneous and visceral white fat at single-cell resolution across a range of body weight. We identify subpopulations of adipocytes, adipose stem and progenitor cells, vascular and immune cells and demonstrate commonalities and differences across species and dietary conditions. We link specific cell types to increased risk of metabolic disease and provide an initial blueprint for a comprehensive set of interactions between individual cell types in the adipose niche in leanness and obesity. These data comprise an extensive resource for the exploration of genes, traits and cell types in the function of white adipose tissue across species, depots and nutritional conditions. 2023-01-11T17:41:57Z 2023-01-11T17:41:57Z 2022 2023-01-11T17:32:41Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/147064 2022. "A single-cell atlas of human and mouse white adipose tissue." Nature, 603 (7903). en 10.1038/S41586-022-04518-2 Nature Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Springer Science and Business Media LLC PMC
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| spellingShingle |
A single-cell atlas of human and mouse white adipose tissue
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| title |
A single-cell atlas of human and mouse white adipose tissue
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| title_full |
A single-cell atlas of human and mouse white adipose tissue
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| title_fullStr |
A single-cell atlas of human and mouse white adipose tissue
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| title_full_unstemmed |
A single-cell atlas of human and mouse white adipose tissue
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| title_short |
A single-cell atlas of human and mouse white adipose tissue
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| title_sort |
single cell atlas of human and mouse white adipose tissue
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| url |
https://hdl.handle.net/1721.1/147064
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