Stepwise-edited, human melanoma models reveal mutations’ effect on tumor and microenvironment

Stepwise-edited, human melanoma models reveal mutations’ effect on tumor and microenvironment

<jats:p>Establishing causal relationships between genetic alterations of human cancers and specific phenotypes of malignancy remains a challenge. We sequentially introduced mutations into healthy human melanocytes in up to five genes spanning six commonly disrupted melanoma pathways, forming n...

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Bibliographic Details
Main Authors: Hodis, Eran, Triglia, Elena Torlai, Kwon, John YH, Biancalani, Tommaso, Zakka, Labib R, Parkar, Saurabh, Hütter, Jan-Christian, Buffoni, Lorenzo, Delorey, Toni M, Phillips, Devan, Dionne, Danielle, Nguyen, Lan T, Schapiro, Denis, Maliga, Zoltan, Jacobson, Connor A, Hendel, Ayal, Rozenblatt-Rosen, Orit, Mihm, Martin C, Garraway, Levi A, Regev, Aviv
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2023
Online Access:https://hdl.handle.net/1721.1/147070

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