Sequre: a high-performance framework for secure multiparty computation enables biomedical data sharing

Abstract Secure multiparty computation (MPC) is a cryptographic tool that allows computation on top of sensitive biomedical data without revealing private information to the involved entities. Here, we introduce Sequre, an easy-to-use, high-performance framework for developing perform...

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Bibliographic Details
Main Authors: Smajlović, Haris, Shajii, Ariya, Berger, Bonnie, Cho, Hyunghoon, Numanagić, Ibrahim
Other Authors: Massachusetts Institute of Technology. Department of Mathematics
Format: Article
Language:English
Published: BioMed Central 2023
Online Access:https://hdl.handle.net/1721.1/147111
Description
Summary:Abstract Secure multiparty computation (MPC) is a cryptographic tool that allows computation on top of sensitive biomedical data without revealing private information to the involved entities. Here, we introduce Sequre, an easy-to-use, high-performance framework for developing performant MPC applications. Sequre offers a set of automatic compile-time optimizations that significantly improve the performance of MPC applications and incorporates the syntax of Python programming language to facilitate rapid application development. We demonstrate its usability and performance on various bioinformatics tasks showing up to 3–4 times increased speed over the existing pipelines with 7-fold reductions in codebase sizes.