MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts

MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts

The MYCN oncoprotein drives the development of numerous neuroendocrine and pediatric tumors. Here we show that MYCN interacts with the nuclear RNA exosome, a 3'-5' exoribonuclease complex, and recruits the exosome to its target genes. In the absence of the exosome, MYCN-directed elongation...

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Bibliographic Details
Main Authors: Papadopoulos, Dimitrios, Solvie, Daniel, Baluapuri, Apoorva, Endres, Theresa, Ha, Stefanie Anh, Herold, Steffi, Kalb, Jacqueline, Giansanti, Celeste, Schülein-Völk, Christina, Ade, Carsten Patrick, Schneider, Cornelius, Gaballa, Abdallah, Vos, Seychelle, Fischer, Utz, Dobbelstein, Matthias, Wolf, Elmar, Eilers, Martin
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Elsevier BV 2023
Online Access:https://hdl.handle.net/1721.1/147120

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