Mechanisms of Neuroinvasion and Neuropathogenesis by Pathologic Flaviviruses
Flaviviruses are present on every continent and cause significant morbidity and mortality. In many instances, severe cases of infection with flaviviruses involve the invasion of and damage to the central nervous system (CNS). Currently, there are several mechanisms by which it has been hypothesized...
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| Format: | Article |
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Multidisciplinary Digital Publishing Institute
2023
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| Online Access: | https://hdl.handle.net/1721.1/147607 |
| _version_ | 1826191526996213760 |
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| author | de Vries, Liset Harding, Alfred T. |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science de Vries, Liset Harding, Alfred T. |
| author_sort | de Vries, Liset |
| collection | MIT |
| description | Flaviviruses are present on every continent and cause significant morbidity and mortality. In many instances, severe cases of infection with flaviviruses involve the invasion of and damage to the central nervous system (CNS). Currently, there are several mechanisms by which it has been hypothesized flaviviruses reach the brain, including the disruption of the blood–brain barrier (BBB) which acts as a first line of defense by blocking the entry of many pathogens into the brain, passing through the BBB without disruption, as well as travelling into the CNS through axonal transport from peripheral nerves. After flaviviruses have entered the CNS, they cause different neurological symptoms, leading to years of neurological sequelae or even death. Similar to neuroinvasion, there are several identified mechanisms of neuropathology, including direct cell lysis, blockage of the cell cycle, indication of apoptosis, as well as immune induced pathologies. In this review, we aim to summarize the current knowledge in the field of mechanisms of both neuroinvasion and neuropathogenesis during infection with a variety of flaviviruses and examine the potential contributions and timing of each discussed pathway. |
| first_indexed | 2024-09-23T08:57:14Z |
| format | Article |
| id | mit-1721.1/147607 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T08:57:14Z |
| publishDate | 2023 |
| publisher | Multidisciplinary Digital Publishing Institute |
| record_format | dspace |
| spelling | mit-1721.1/1476072024-03-20T20:05:24Z Mechanisms of Neuroinvasion and Neuropathogenesis by Pathologic Flaviviruses de Vries, Liset Harding, Alfred T. Massachusetts Institute of Technology. Institute for Medical Engineering & Science Flaviviruses are present on every continent and cause significant morbidity and mortality. In many instances, severe cases of infection with flaviviruses involve the invasion of and damage to the central nervous system (CNS). Currently, there are several mechanisms by which it has been hypothesized flaviviruses reach the brain, including the disruption of the blood–brain barrier (BBB) which acts as a first line of defense by blocking the entry of many pathogens into the brain, passing through the BBB without disruption, as well as travelling into the CNS through axonal transport from peripheral nerves. After flaviviruses have entered the CNS, they cause different neurological symptoms, leading to years of neurological sequelae or even death. Similar to neuroinvasion, there are several identified mechanisms of neuropathology, including direct cell lysis, blockage of the cell cycle, indication of apoptosis, as well as immune induced pathologies. In this review, we aim to summarize the current knowledge in the field of mechanisms of both neuroinvasion and neuropathogenesis during infection with a variety of flaviviruses and examine the potential contributions and timing of each discussed pathway. 2023-01-20T16:15:17Z 2023-01-20T16:15:17Z 2023-01-17 2023-01-20T14:23:13Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/147607 Viruses 15 (2): 261 (2023) PUBLISHER_CC http://dx.doi.org/10.3390/v15020261 Creative Commons Attribution https://creativecommons.org/licenses/by/4.0/ application/pdf Multidisciplinary Digital Publishing Institute Multidisciplinary Digital Publishing Institute |
| spellingShingle | de Vries, Liset Harding, Alfred T. Mechanisms of Neuroinvasion and Neuropathogenesis by Pathologic Flaviviruses |
| title | Mechanisms of Neuroinvasion and Neuropathogenesis by Pathologic Flaviviruses |
| title_full | Mechanisms of Neuroinvasion and Neuropathogenesis by Pathologic Flaviviruses |
| title_fullStr | Mechanisms of Neuroinvasion and Neuropathogenesis by Pathologic Flaviviruses |
| title_full_unstemmed | Mechanisms of Neuroinvasion and Neuropathogenesis by Pathologic Flaviviruses |
| title_short | Mechanisms of Neuroinvasion and Neuropathogenesis by Pathologic Flaviviruses |
| title_sort | mechanisms of neuroinvasion and neuropathogenesis by pathologic flaviviruses |
| url | https://hdl.handle.net/1721.1/147607 |
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