Nationwide Trends in COVID-19 Cases and SARS-CoV-2 RNA Wastewater Concentrations in the United States
Wastewater-based epidemiology has emerged as a promising technology for population-level surveillance of COVID-19. In this study, we present results of a large nationwide SARS-CoV-2 wastewater monitoring system in the United States. We profile 55 locations with at least six months of sampling from A...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society (ACS)
2023
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| Online Access: | https://hdl.handle.net/1721.1/147742 |
| _version_ | 1811078697463054336 |
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| author | Duvallet, Claire Wu, Fuqing McElroy, Kyle A Imakaev, Maxim Endo, Noriko Xiao, Amy Zhang, Jianbo Floyd-O’Sullivan, Róisín Powell, Morgan M Mendola, Samuel Wilson, Shane T Cruz, Francis Melman, Tamar Sathyanarayana, Chaithra Lakshmi Olesen, Scott W Erickson, Timothy B Ghaeli, Newsha Chai, Peter Alm, Eric J Matus, Mariana |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Duvallet, Claire Wu, Fuqing McElroy, Kyle A Imakaev, Maxim Endo, Noriko Xiao, Amy Zhang, Jianbo Floyd-O’Sullivan, Róisín Powell, Morgan M Mendola, Samuel Wilson, Shane T Cruz, Francis Melman, Tamar Sathyanarayana, Chaithra Lakshmi Olesen, Scott W Erickson, Timothy B Ghaeli, Newsha Chai, Peter Alm, Eric J Matus, Mariana |
| author_sort | Duvallet, Claire |
| collection | MIT |
| description | Wastewater-based epidemiology has emerged as a promising technology for population-level surveillance of COVID-19. In this study, we present results of a large nationwide SARS-CoV-2 wastewater monitoring system in the United States. We profile 55 locations with at least six months of sampling from April 2020 to May 2021. These locations represent more than 12 million individuals across 19 states. Samples were collected approximately weekly by wastewater treatment utilities as part of a regular wastewater surveillance service and analyzed for SARS-CoV-2 RNA concentrations. SARS-CoV-2 RNA concentrations were normalized to pepper mild mottle virus, an indicator of fecal matter in wastewater. We show that wastewater data reflect temporal and geographic trends in clinical COVID-19 cases and investigate the impact of normalization on correlations with case data within and across locations. We also provide key lessons learned from our broad-scale implementation of wastewater-based epidemiology, which can be used to inform wastewater-based epidemiology approaches for future emerging diseases. This work demonstrates that wastewater surveillance is a feasible approach for nationwide population-level monitoring of COVID-19 disease. With an evolving epidemic and effective vaccines against SARS-CoV-2, wastewater-based epidemiology can serve as a passive surveillance approach for detecting changing dynamics or resurgences of the virus. |
| first_indexed | 2024-09-23T11:04:02Z |
| format | Article |
| id | mit-1721.1/147742 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:04:02Z |
| publishDate | 2023 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/1477422023-01-27T03:34:05Z Nationwide Trends in COVID-19 Cases and SARS-CoV-2 RNA Wastewater Concentrations in the United States Duvallet, Claire Wu, Fuqing McElroy, Kyle A Imakaev, Maxim Endo, Noriko Xiao, Amy Zhang, Jianbo Floyd-O’Sullivan, Róisín Powell, Morgan M Mendola, Samuel Wilson, Shane T Cruz, Francis Melman, Tamar Sathyanarayana, Chaithra Lakshmi Olesen, Scott W Erickson, Timothy B Ghaeli, Newsha Chai, Peter Alm, Eric J Matus, Mariana Massachusetts Institute of Technology. Department of Biological Engineering Wastewater-based epidemiology has emerged as a promising technology for population-level surveillance of COVID-19. In this study, we present results of a large nationwide SARS-CoV-2 wastewater monitoring system in the United States. We profile 55 locations with at least six months of sampling from April 2020 to May 2021. These locations represent more than 12 million individuals across 19 states. Samples were collected approximately weekly by wastewater treatment utilities as part of a regular wastewater surveillance service and analyzed for SARS-CoV-2 RNA concentrations. SARS-CoV-2 RNA concentrations were normalized to pepper mild mottle virus, an indicator of fecal matter in wastewater. We show that wastewater data reflect temporal and geographic trends in clinical COVID-19 cases and investigate the impact of normalization on correlations with case data within and across locations. We also provide key lessons learned from our broad-scale implementation of wastewater-based epidemiology, which can be used to inform wastewater-based epidemiology approaches for future emerging diseases. This work demonstrates that wastewater surveillance is a feasible approach for nationwide population-level monitoring of COVID-19 disease. With an evolving epidemic and effective vaccines against SARS-CoV-2, wastewater-based epidemiology can serve as a passive surveillance approach for detecting changing dynamics or resurgences of the virus. 2023-01-26T17:45:18Z 2023-01-26T17:45:18Z 2022 2023-01-26T17:40:41Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/147742 Duvallet, Claire, Wu, Fuqing, McElroy, Kyle A, Imakaev, Maxim, Endo, Noriko et al. 2022. "Nationwide Trends in COVID-19 Cases and SARS-CoV-2 RNA Wastewater Concentrations in the United States." ACS ES&T Water, 2 (11). en 10.1021/ACSESTWATER.1C00434 ACS ES&T Water Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf American Chemical Society (ACS) ACS |
| spellingShingle | Duvallet, Claire Wu, Fuqing McElroy, Kyle A Imakaev, Maxim Endo, Noriko Xiao, Amy Zhang, Jianbo Floyd-O’Sullivan, Róisín Powell, Morgan M Mendola, Samuel Wilson, Shane T Cruz, Francis Melman, Tamar Sathyanarayana, Chaithra Lakshmi Olesen, Scott W Erickson, Timothy B Ghaeli, Newsha Chai, Peter Alm, Eric J Matus, Mariana Nationwide Trends in COVID-19 Cases and SARS-CoV-2 RNA Wastewater Concentrations in the United States |
| title | Nationwide Trends in COVID-19 Cases and SARS-CoV-2 RNA Wastewater Concentrations in the United States |
| title_full | Nationwide Trends in COVID-19 Cases and SARS-CoV-2 RNA Wastewater Concentrations in the United States |
| title_fullStr | Nationwide Trends in COVID-19 Cases and SARS-CoV-2 RNA Wastewater Concentrations in the United States |
| title_full_unstemmed | Nationwide Trends in COVID-19 Cases and SARS-CoV-2 RNA Wastewater Concentrations in the United States |
| title_short | Nationwide Trends in COVID-19 Cases and SARS-CoV-2 RNA Wastewater Concentrations in the United States |
| title_sort | nationwide trends in covid 19 cases and sars cov 2 rna wastewater concentrations in the united states |
| url | https://hdl.handle.net/1721.1/147742 |
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