MEK inhibition enhances presentation of targetable MHC-I tumor antigens in mutant melanomas
<jats:p>Combining multiple therapeutic strategies in NRAS/BRAF mutant melanoma—namely MEK/BRAF kinase inhibitors, immune checkpoint inhibitors (ICIs), and targeted immunotherapies—may offer an improved survival benefit by overcoming limitations associated with any individual therapy. Still, op...
Main Authors: | Stopfer, Lauren E, Rettko, Nicholas J, Leddy, Owen, Mesfin, Joshua M, Brown, Eric, Winski, Shannon, Bryson, Bryan, Wells, James A, White, Forest M |
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Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering |
Format: | Article |
Language: | English |
Published: |
Proceedings of the National Academy of Sciences
2023
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Online Access: | https://hdl.handle.net/1721.1/147778 |
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