CRISPR Interference Reveals That All- Trans -Retinoic Acid Promotes Macrophage Control of Mycobacterium tuberculosis by Limiting Bacterial Access to Cholesterol and Propionyl Coenzyme A
<jats:p> Tuberculosis, caused by the bacterium <jats:named-content content-type="genus-species">Mycobacterium tuberculosis</jats:named-content> , is a leading cause of death due to infectious disease. Improving the immune response to...
| Main Authors: | , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2023
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| Online Access: | https://hdl.handle.net/1721.1/147781 |
| _version_ | 1811000098088288256 |
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| author | Babunovic, Gregory H DeJesus, Michael A Bosch, Barbara Chase, Michael R Barbier, Thibault Dickey, Amy K Bryson, Bryan D Rock, Jeremy M Fortune, Sarah M |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Babunovic, Gregory H DeJesus, Michael A Bosch, Barbara Chase, Michael R Barbier, Thibault Dickey, Amy K Bryson, Bryan D Rock, Jeremy M Fortune, Sarah M |
| author_sort | Babunovic, Gregory H |
| collection | MIT |
| description | <jats:p>
Tuberculosis, caused by the bacterium
<jats:named-content content-type="genus-species">Mycobacterium tuberculosis</jats:named-content>
, is a leading cause of death due to infectious disease. Improving the immune response to tuberculosis holds promise for fighting the disease but is limited by our lack of knowledge as to how the immune system kills
<jats:named-content content-type="genus-species">M. tuberculosis</jats:named-content>
.
</jats:p> |
| first_indexed | 2024-09-23T15:11:20Z |
| format | Article |
| id | mit-1721.1/147781 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T15:11:20Z |
| publishDate | 2023 |
| publisher | American Society for Microbiology |
| record_format | dspace |
| spelling | mit-1721.1/1477812024-01-19T21:16:52Z CRISPR Interference Reveals That All- Trans -Retinoic Acid Promotes Macrophage Control of Mycobacterium tuberculosis by Limiting Bacterial Access to Cholesterol and Propionyl Coenzyme A Babunovic, Gregory H DeJesus, Michael A Bosch, Barbara Chase, Michael R Barbier, Thibault Dickey, Amy K Bryson, Bryan D Rock, Jeremy M Fortune, Sarah M Massachusetts Institute of Technology. Department of Biological Engineering <jats:p> Tuberculosis, caused by the bacterium <jats:named-content content-type="genus-species">Mycobacterium tuberculosis</jats:named-content> , is a leading cause of death due to infectious disease. Improving the immune response to tuberculosis holds promise for fighting the disease but is limited by our lack of knowledge as to how the immune system kills <jats:named-content content-type="genus-species">M. tuberculosis</jats:named-content> . </jats:p> 2023-01-30T15:15:22Z 2023-01-30T15:15:22Z 2022 2023-01-30T15:12:48Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/147781 Babunovic, Gregory H, DeJesus, Michael A, Bosch, Barbara, Chase, Michael R, Barbier, Thibault et al. 2022. "CRISPR Interference Reveals That All- Trans -Retinoic Acid Promotes Macrophage Control of Mycobacterium tuberculosis by Limiting Bacterial Access to Cholesterol and Propionyl Coenzyme A." mBio, 13 (1). en 10.1128/MBIO.03683-21 mBio Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf American Society for Microbiology mBio |
| spellingShingle | Babunovic, Gregory H DeJesus, Michael A Bosch, Barbara Chase, Michael R Barbier, Thibault Dickey, Amy K Bryson, Bryan D Rock, Jeremy M Fortune, Sarah M CRISPR Interference Reveals That All- Trans -Retinoic Acid Promotes Macrophage Control of Mycobacterium tuberculosis by Limiting Bacterial Access to Cholesterol and Propionyl Coenzyme A |
| title | CRISPR Interference Reveals That All- Trans -Retinoic Acid Promotes Macrophage Control of Mycobacterium tuberculosis by Limiting Bacterial Access to Cholesterol and Propionyl Coenzyme A |
| title_full | CRISPR Interference Reveals That All- Trans -Retinoic Acid Promotes Macrophage Control of Mycobacterium tuberculosis by Limiting Bacterial Access to Cholesterol and Propionyl Coenzyme A |
| title_fullStr | CRISPR Interference Reveals That All- Trans -Retinoic Acid Promotes Macrophage Control of Mycobacterium tuberculosis by Limiting Bacterial Access to Cholesterol and Propionyl Coenzyme A |
| title_full_unstemmed | CRISPR Interference Reveals That All- Trans -Retinoic Acid Promotes Macrophage Control of Mycobacterium tuberculosis by Limiting Bacterial Access to Cholesterol and Propionyl Coenzyme A |
| title_short | CRISPR Interference Reveals That All- Trans -Retinoic Acid Promotes Macrophage Control of Mycobacterium tuberculosis by Limiting Bacterial Access to Cholesterol and Propionyl Coenzyme A |
| title_sort | crispr interference reveals that all trans retinoic acid promotes macrophage control of mycobacterium tuberculosis by limiting bacterial access to cholesterol and propionyl coenzyme a |
| url | https://hdl.handle.net/1721.1/147781 |
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