Structure-guided changes at the V2 apex of HIV-1 clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies

Structure-guided changes at the V2 apex of HIV-1 clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies

HIV-1 clade C envelope immunogens that elicit both neutralizing and non-neutralizing V1V2-scaffold-specific antibodies (protective correlates from RV144 human trial) are urgently needed due to the prevalence of this clade in the most impacted regions worldwide. To achieve this, we introduce structur...

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Bibliographic Details
Main Authors: Sahoo, Anusmita, Hodge, Edgar A, LaBranche, Celia C, Styles, Tiffany M, Shen, Xiaoying, Cheedarla, Narayanaiah, Shiferaw, Ayalnesh, Ozorowski, Gabriel, Lee, Wen-Hsin, Ward, Andrew B, Tomaras, Georgia D, Montefiori, David C, Irvine, Darrell J, Lee, Kelly K, Amara, Rama Rao
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: Elsevier BV 2023
Online Access:https://hdl.handle.net/1721.1/147834

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