A Mycobacterium tuberculosis Specific IgG3 Signature of Recurrent Tuberculosis
<jats:p>South Africa has the highest prevalence of HIV and tuberculosis (TB) co-infection globally. Recurrent TB, caused by relapse or reinfection, makes up the majority of TB cases in South Africa, and HIV infected individuals have a greater likelihood of developing recurrent TB. Given that T...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media SA
2023
|
| Online Access: | https://hdl.handle.net/1721.1/147853 |
| _version_ | 1811081881987317760 |
|---|---|
| author | Fischinger, Stephanie Cizmeci, Deniz Shin, Sally Davies, Leela Grace, Patricia S Sivro, Aida Yende-Zuma, Nonhlanhla Streeck, Hendrik Fortune, Sarah M Lauffenburger, Douglas A Naidoo, Kogieleum Alter, Galit |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Fischinger, Stephanie Cizmeci, Deniz Shin, Sally Davies, Leela Grace, Patricia S Sivro, Aida Yende-Zuma, Nonhlanhla Streeck, Hendrik Fortune, Sarah M Lauffenburger, Douglas A Naidoo, Kogieleum Alter, Galit |
| author_sort | Fischinger, Stephanie |
| collection | MIT |
| description | <jats:p>South Africa has the highest prevalence of HIV and tuberculosis (TB) co-infection globally. Recurrent TB, caused by relapse or reinfection, makes up the majority of TB cases in South Africa, and HIV infected individuals have a greater likelihood of developing recurrent TB. Given that TB remains a leading cause of death for HIV infected individuals, and correlates of TB recurrence protection/risk have yet to be defined, here we sought to understand the antibody associated mechanisms of recurrent TB by investigating the humoral response in a longitudinal cohort of HIV co-infected individuals previously treated for TB with and without recurrent disease during follow-up, in order to identify antibody correlates of protection between individuals who do not have recurrent TB and individuals who do. We used a high-throughput, “systems serology” approach to profile biophysical and functional characteristics of antibodies targeting antigens from <jats:italic>Mycobacterium tuberculosis (Mtb)</jats:italic>. Differences in antibody profiles were noted between individuals with and without recurrent TB, albeit these differences were largely observed close to the time of re-diagnosis. Individuals with recurrent TB had decreased <jats:italic>Mtb</jats:italic>-antigen specific IgG3 titers, but not other IgG subclasses or IgA, compared to control individuals. These data point to a potential role for <jats:italic>Mtb</jats:italic>-specific IgG3 responses as biomarkers or direct mediators of protective immunity against <jats:italic>Mtb</jats:italic> recurrence.</jats:p> |
| first_indexed | 2024-09-23T11:53:53Z |
| format | Article |
| id | mit-1721.1/147853 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:53:53Z |
| publishDate | 2023 |
| publisher | Frontiers Media SA |
| record_format | dspace |
| spelling | mit-1721.1/1478532023-02-04T03:28:14Z A Mycobacterium tuberculosis Specific IgG3 Signature of Recurrent Tuberculosis Fischinger, Stephanie Cizmeci, Deniz Shin, Sally Davies, Leela Grace, Patricia S Sivro, Aida Yende-Zuma, Nonhlanhla Streeck, Hendrik Fortune, Sarah M Lauffenburger, Douglas A Naidoo, Kogieleum Alter, Galit Massachusetts Institute of Technology. Department of Biological Engineering <jats:p>South Africa has the highest prevalence of HIV and tuberculosis (TB) co-infection globally. Recurrent TB, caused by relapse or reinfection, makes up the majority of TB cases in South Africa, and HIV infected individuals have a greater likelihood of developing recurrent TB. Given that TB remains a leading cause of death for HIV infected individuals, and correlates of TB recurrence protection/risk have yet to be defined, here we sought to understand the antibody associated mechanisms of recurrent TB by investigating the humoral response in a longitudinal cohort of HIV co-infected individuals previously treated for TB with and without recurrent disease during follow-up, in order to identify antibody correlates of protection between individuals who do not have recurrent TB and individuals who do. We used a high-throughput, “systems serology” approach to profile biophysical and functional characteristics of antibodies targeting antigens from <jats:italic>Mycobacterium tuberculosis (Mtb)</jats:italic>. Differences in antibody profiles were noted between individuals with and without recurrent TB, albeit these differences were largely observed close to the time of re-diagnosis. Individuals with recurrent TB had decreased <jats:italic>Mtb</jats:italic>-antigen specific IgG3 titers, but not other IgG subclasses or IgA, compared to control individuals. These data point to a potential role for <jats:italic>Mtb</jats:italic>-specific IgG3 responses as biomarkers or direct mediators of protective immunity against <jats:italic>Mtb</jats:italic> recurrence.</jats:p> 2023-02-03T15:47:22Z 2023-02-03T15:47:22Z 2021 2023-02-03T13:10:14Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/147853 Fischinger, Stephanie, Cizmeci, Deniz, Shin, Sally, Davies, Leela, Grace, Patricia S et al. 2021. "A Mycobacterium tuberculosis Specific IgG3 Signature of Recurrent Tuberculosis." Frontiers in Immunology, 12. en 10.3389/FIMMU.2021.729186 Frontiers in Immunology Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Frontiers Media SA Frontiers |
| spellingShingle | Fischinger, Stephanie Cizmeci, Deniz Shin, Sally Davies, Leela Grace, Patricia S Sivro, Aida Yende-Zuma, Nonhlanhla Streeck, Hendrik Fortune, Sarah M Lauffenburger, Douglas A Naidoo, Kogieleum Alter, Galit A Mycobacterium tuberculosis Specific IgG3 Signature of Recurrent Tuberculosis |
| title | A Mycobacterium tuberculosis Specific IgG3 Signature of Recurrent Tuberculosis |
| title_full | A Mycobacterium tuberculosis Specific IgG3 Signature of Recurrent Tuberculosis |
| title_fullStr | A Mycobacterium tuberculosis Specific IgG3 Signature of Recurrent Tuberculosis |
| title_full_unstemmed | A Mycobacterium tuberculosis Specific IgG3 Signature of Recurrent Tuberculosis |
| title_short | A Mycobacterium tuberculosis Specific IgG3 Signature of Recurrent Tuberculosis |
| title_sort | mycobacterium tuberculosis specific igg3 signature of recurrent tuberculosis |
| url | https://hdl.handle.net/1721.1/147853 |
| work_keys_str_mv | AT fischingerstephanie amycobacteriumtuberculosisspecificigg3signatureofrecurrenttuberculosis AT cizmecideniz amycobacteriumtuberculosisspecificigg3signatureofrecurrenttuberculosis AT shinsally amycobacteriumtuberculosisspecificigg3signatureofrecurrenttuberculosis AT daviesleela amycobacteriumtuberculosisspecificigg3signatureofrecurrenttuberculosis AT gracepatricias amycobacteriumtuberculosisspecificigg3signatureofrecurrenttuberculosis AT sivroaida amycobacteriumtuberculosisspecificigg3signatureofrecurrenttuberculosis AT yendezumanonhlanhla amycobacteriumtuberculosisspecificigg3signatureofrecurrenttuberculosis AT streeckhendrik amycobacteriumtuberculosisspecificigg3signatureofrecurrenttuberculosis AT fortunesarahm amycobacteriumtuberculosisspecificigg3signatureofrecurrenttuberculosis AT lauffenburgerdouglasa amycobacteriumtuberculosisspecificigg3signatureofrecurrenttuberculosis AT naidookogieleum amycobacteriumtuberculosisspecificigg3signatureofrecurrenttuberculosis AT altergalit amycobacteriumtuberculosisspecificigg3signatureofrecurrenttuberculosis AT fischingerstephanie mycobacteriumtuberculosisspecificigg3signatureofrecurrenttuberculosis AT cizmecideniz mycobacteriumtuberculosisspecificigg3signatureofrecurrenttuberculosis AT shinsally mycobacteriumtuberculosisspecificigg3signatureofrecurrenttuberculosis AT daviesleela mycobacteriumtuberculosisspecificigg3signatureofrecurrenttuberculosis AT gracepatricias mycobacteriumtuberculosisspecificigg3signatureofrecurrenttuberculosis AT sivroaida mycobacteriumtuberculosisspecificigg3signatureofrecurrenttuberculosis AT yendezumanonhlanhla mycobacteriumtuberculosisspecificigg3signatureofrecurrenttuberculosis AT streeckhendrik mycobacteriumtuberculosisspecificigg3signatureofrecurrenttuberculosis AT fortunesarahm mycobacteriumtuberculosisspecificigg3signatureofrecurrenttuberculosis AT lauffenburgerdouglasa mycobacteriumtuberculosisspecificigg3signatureofrecurrenttuberculosis AT naidookogieleum mycobacteriumtuberculosisspecificigg3signatureofrecurrenttuberculosis AT altergalit mycobacteriumtuberculosisspecificigg3signatureofrecurrenttuberculosis |