Hybrid Immunity Shifts the Fc-Effector Quality of SARS-CoV-2 mRNA Vaccine-Induced Immunity

Hybrid Immunity Shifts the Fc-Effector Quality of SARS-CoV-2 mRNA Vaccine-Induced Immunity

<jats:p>Recent data indicates improved immunity to SARS-CoV-2 in individuals who experience a combination of two mRNA vaccine doses and infection, “hybrid immunity,” compared to individuals who receive vaccination or experience infection alone. While previous infection accelerates the vaccine-...

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Bibliographic Details
Main Authors: Bowman, Kathryn A, Stein, Daniel, Shin, Sally, Ferbas, Kathie G, Tobin, Nicole H, Mann, Colin, Fischinger, Stephanie, Ollmann Saphire, Erica, Lauffenburger, Douglas, Rimoin, Anne W, Aldrovandi, Grace, Alter, Galit
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: American Society for Microbiology 2023
Online Access:https://hdl.handle.net/1721.1/147858
Description
Summary:<jats:p>Recent data indicates improved immunity to SARS-CoV-2 in individuals who experience a combination of two mRNA vaccine doses and infection, “hybrid immunity,” compared to individuals who receive vaccination or experience infection alone. While previous infection accelerates the vaccine-induced immune response following the first dose of mRNA vaccination, subsequent doses demonstrate negligible increases in antibody titers or T cell immunity.</jats:p>

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