Selective functional antibody transfer into the breastmilk after SARS-CoV-2 infection
Antibody transfer via breastmilk represents an evolutionary strategy to boost immunity in early life. Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibodies have been observed in the breastmilk, the functional quality of these antibodies remains unclear. Here, we a...
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Elsevier BV
2023
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| Mynediad Ar-lein: | https://hdl.handle.net/1721.1/147860 |
| _version_ | 1826193573029085184 |
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| author | Pullen, Krista M Atyeo, Caroline Collier, Ai-Ris Y Gray, Kathryn J Belfort, Mandy B Lauffenburger, Douglas A Edlow, Andrea G Alter, Galit |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Pullen, Krista M Atyeo, Caroline Collier, Ai-Ris Y Gray, Kathryn J Belfort, Mandy B Lauffenburger, Douglas A Edlow, Andrea G Alter, Galit |
| author_sort | Pullen, Krista M |
| collection | MIT |
| description | Antibody transfer via breastmilk represents an evolutionary strategy to boost immunity in early life. Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibodies have been observed in the breastmilk, the functional quality of these antibodies remains unclear. Here, we apply systems serology to characterize SARS-CoV-2-specific antibodies in maternal serum and breastmilk to compare the functional characteristics of antibodies in these fluids. Distinct SARS-CoV-2-specific antibody responses are observed in the serum and breastmilk of lactating individuals previously infected with SARS-CoV-2, with a more dominant transfer of immunoglobulin A (IgA) and IgM into breastmilk. Although IgGs are present in breastmilk, they are functionally attenuated. We observe preferential transfer of antibodies capable of eliciting neutrophil phagocytosis and neutralization compared to other functions, pointing to selective transfer of certain functional antibodies to breastmilk. These data highlight the preferential transfer of SARS-CoV-2-specific IgA and IgM to breastmilk, accompanied by select IgG subpopulations, positioned to create a non-pathologic but protective barrier against coronavirus disease 2019 (COVID-19). |
| first_indexed | 2024-09-23T09:41:15Z |
| format | Article |
| id | mit-1721.1/147860 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:41:15Z |
| publishDate | 2023 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1478602023-02-04T03:40:57Z Selective functional antibody transfer into the breastmilk after SARS-CoV-2 infection Pullen, Krista M Atyeo, Caroline Collier, Ai-Ris Y Gray, Kathryn J Belfort, Mandy B Lauffenburger, Douglas A Edlow, Andrea G Alter, Galit Massachusetts Institute of Technology. Department of Biological Engineering Antibody transfer via breastmilk represents an evolutionary strategy to boost immunity in early life. Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibodies have been observed in the breastmilk, the functional quality of these antibodies remains unclear. Here, we apply systems serology to characterize SARS-CoV-2-specific antibodies in maternal serum and breastmilk to compare the functional characteristics of antibodies in these fluids. Distinct SARS-CoV-2-specific antibody responses are observed in the serum and breastmilk of lactating individuals previously infected with SARS-CoV-2, with a more dominant transfer of immunoglobulin A (IgA) and IgM into breastmilk. Although IgGs are present in breastmilk, they are functionally attenuated. We observe preferential transfer of antibodies capable of eliciting neutrophil phagocytosis and neutralization compared to other functions, pointing to selective transfer of certain functional antibodies to breastmilk. These data highlight the preferential transfer of SARS-CoV-2-specific IgA and IgM to breastmilk, accompanied by select IgG subpopulations, positioned to create a non-pathologic but protective barrier against coronavirus disease 2019 (COVID-19). 2023-02-03T17:24:42Z 2023-02-03T17:24:42Z 2021 2023-02-03T17:19:21Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/147860 Pullen, Krista M, Atyeo, Caroline, Collier, Ai-Ris Y, Gray, Kathryn J, Belfort, Mandy B et al. 2021. "Selective functional antibody transfer into the breastmilk after SARS-CoV-2 infection." Cell Reports, 37 (6). en 10.1016/J.CELREP.2021.109959 Cell Reports Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Elsevier BV Cell Reports |
| spellingShingle | Pullen, Krista M Atyeo, Caroline Collier, Ai-Ris Y Gray, Kathryn J Belfort, Mandy B Lauffenburger, Douglas A Edlow, Andrea G Alter, Galit Selective functional antibody transfer into the breastmilk after SARS-CoV-2 infection |
| title | Selective functional antibody transfer into the breastmilk after SARS-CoV-2 infection |
| title_full | Selective functional antibody transfer into the breastmilk after SARS-CoV-2 infection |
| title_fullStr | Selective functional antibody transfer into the breastmilk after SARS-CoV-2 infection |
| title_full_unstemmed | Selective functional antibody transfer into the breastmilk after SARS-CoV-2 infection |
| title_short | Selective functional antibody transfer into the breastmilk after SARS-CoV-2 infection |
| title_sort | selective functional antibody transfer into the breastmilk after sars cov 2 infection |
| url | https://hdl.handle.net/1721.1/147860 |
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