Selective transfer of maternal antibodies in preterm and fullterm children
Preterm newborns are more likely to suffer from infectious diseases at birth compared to children delivered at term. Whether this is due to compromised cellular, humoral, or organ-specific development remains unclear. To begin to define whether maternal–fetal antibody transfer profiles differ across...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Springer Science and Business Media LLC
2023
|
| Online Access: | https://hdl.handle.net/1721.1/147861 |
| _version_ | 1811091355254915072 |
|---|---|
| author | Dolatshahi, Sepideh Butler, Audrey L Pou, Christian Henckel, Ewa Bernhardsson, Anna Karin Gustafsson, Anna Bohlin, Kajsa Shin, Sally A Lauffenburger, Douglas A Brodin, Petter Alter, Galit |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Dolatshahi, Sepideh Butler, Audrey L Pou, Christian Henckel, Ewa Bernhardsson, Anna Karin Gustafsson, Anna Bohlin, Kajsa Shin, Sally A Lauffenburger, Douglas A Brodin, Petter Alter, Galit |
| author_sort | Dolatshahi, Sepideh |
| collection | MIT |
| description | Preterm newborns are more likely to suffer from infectious diseases at birth compared to children delivered at term. Whether this is due to compromised cellular, humoral, or organ-specific development remains unclear. To begin to define whether maternal–fetal antibody transfer profiles differ across preterm (PT) and fullterm (FT) infants, the overall quantity and functional quality of an array of 24 vaccine-, endemic pathogen-, and common antigen-specific antibodies were assessed across a cohort of 11 PT and 12 term-delivered maternal:infant pairs from birth through week 12. While total IgG levels to influenza, pneumo, measles, rubella, EBV, and RSV were higher in FT newborns, selective Fc-receptor binding antibodies was noted in PT newborns. In fact, near equivalent antibody-effector functions were observed across PT and FT infants, despite significant quantitative differences in transferred antibody levels. Moreover, temporal transfer analysis revealed the selective early transfer of FcRn, FcγR2, and FcγR3 binding antibodies, pointing to differential placental sieving mechanisms across gestation. These data point to selectivity in placental transfer at distinct gestational ages, to ensure that children are endowed with the most robust humoral immunity even if born preterm. |
| first_indexed | 2024-09-23T15:01:10Z |
| format | Article |
| id | mit-1721.1/147861 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T15:01:10Z |
| publishDate | 2023 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/1478612023-02-04T03:10:14Z Selective transfer of maternal antibodies in preterm and fullterm children Dolatshahi, Sepideh Butler, Audrey L Pou, Christian Henckel, Ewa Bernhardsson, Anna Karin Gustafsson, Anna Bohlin, Kajsa Shin, Sally A Lauffenburger, Douglas A Brodin, Petter Alter, Galit Massachusetts Institute of Technology. Department of Biological Engineering Preterm newborns are more likely to suffer from infectious diseases at birth compared to children delivered at term. Whether this is due to compromised cellular, humoral, or organ-specific development remains unclear. To begin to define whether maternal–fetal antibody transfer profiles differ across preterm (PT) and fullterm (FT) infants, the overall quantity and functional quality of an array of 24 vaccine-, endemic pathogen-, and common antigen-specific antibodies were assessed across a cohort of 11 PT and 12 term-delivered maternal:infant pairs from birth through week 12. While total IgG levels to influenza, pneumo, measles, rubella, EBV, and RSV were higher in FT newborns, selective Fc-receptor binding antibodies was noted in PT newborns. In fact, near equivalent antibody-effector functions were observed across PT and FT infants, despite significant quantitative differences in transferred antibody levels. Moreover, temporal transfer analysis revealed the selective early transfer of FcRn, FcγR2, and FcγR3 binding antibodies, pointing to differential placental sieving mechanisms across gestation. These data point to selectivity in placental transfer at distinct gestational ages, to ensure that children are endowed with the most robust humoral immunity even if born preterm. 2023-02-03T17:41:46Z 2023-02-03T17:41:46Z 2022 2023-02-03T17:24:18Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/147861 Dolatshahi, Sepideh, Butler, Audrey L, Pou, Christian, Henckel, Ewa, Bernhardsson, Anna Karin et al. 2022. "Selective transfer of maternal antibodies in preterm and fullterm children." Scientific Reports, 12 (1). en 10.1038/S41598-022-18973-4 Scientific Reports Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Springer Science and Business Media LLC Scientific Reports |
| spellingShingle | Dolatshahi, Sepideh Butler, Audrey L Pou, Christian Henckel, Ewa Bernhardsson, Anna Karin Gustafsson, Anna Bohlin, Kajsa Shin, Sally A Lauffenburger, Douglas A Brodin, Petter Alter, Galit Selective transfer of maternal antibodies in preterm and fullterm children |
| title | Selective transfer of maternal antibodies in preterm and fullterm children |
| title_full | Selective transfer of maternal antibodies in preterm and fullterm children |
| title_fullStr | Selective transfer of maternal antibodies in preterm and fullterm children |
| title_full_unstemmed | Selective transfer of maternal antibodies in preterm and fullterm children |
| title_short | Selective transfer of maternal antibodies in preterm and fullterm children |
| title_sort | selective transfer of maternal antibodies in preterm and fullterm children |
| url | https://hdl.handle.net/1721.1/147861 |
| work_keys_str_mv | AT dolatshahisepideh selectivetransferofmaternalantibodiesinpretermandfulltermchildren AT butleraudreyl selectivetransferofmaternalantibodiesinpretermandfulltermchildren AT pouchristian selectivetransferofmaternalantibodiesinpretermandfulltermchildren AT henckelewa selectivetransferofmaternalantibodiesinpretermandfulltermchildren AT bernhardssonannakarin selectivetransferofmaternalantibodiesinpretermandfulltermchildren AT gustafssonanna selectivetransferofmaternalantibodiesinpretermandfulltermchildren AT bohlinkajsa selectivetransferofmaternalantibodiesinpretermandfulltermchildren AT shinsallya selectivetransferofmaternalantibodiesinpretermandfulltermchildren AT lauffenburgerdouglasa selectivetransferofmaternalantibodiesinpretermandfulltermchildren AT brodinpetter selectivetransferofmaternalantibodiesinpretermandfulltermchildren AT altergalit selectivetransferofmaternalantibodiesinpretermandfulltermchildren |