Inhibitors of ApiAP2 protein DNA binding exhibit multistage activity against Plasmodium parasites

Inhibitors of ApiAP2 protein DNA binding exhibit multistage activity against Plasmodium parasites

<jats:p><jats:italic>Plasmodium</jats:italic> parasites are reliant on the Apicomplexan AP2 (ApiAP2) transcription factor family to regulate gene expression programs. AP2 DNA binding domains have no homologs in the human or mosquito host genomes, making them potential antimalarial...

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Bibliographic Details
Main Authors: Russell, Timothy James, De Silva, Erandi K, Crowley, Valerie M, Shaw-Saliba, Kathryn, Dube, Namita, Josling, Gabrielle, Pasaje, Charisse Flerida A, Kouskoumvekaki, Irene, Panagiotou, Gianni, Niles, Jacquin C, Jacobs-Lorena, Marcelo, Denise Okafor, C, Gamo, Francisco-Javier, Llinás, Manuel
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023
Online Access:https://hdl.handle.net/1721.1/147888

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