Pharmacokinetics and biodistribution of extracellular vesicles administered intravenously and intranasally to Macaca nemestrina

Pharmacokinetics and biodistribution of extracellular vesicles administered intravenously and intranasally to Macaca nemestrina

Extracellular vesicles (EVs) have potential in disease treatment since they can be loaded with therapeutic molecules and engineered for retention by specific tissues. However, questions remain on optimal dosing, administration, and pharmacokinetics. Previous studies have addressed biodistribution an...

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Bibliographic Details
Main Authors: Driedonks, Tom, Jiang, Linglei, Carlson, Bess, Han, Zheng, Liu, Guanshu, Queen, Suzanne E, Shirk, Erin N, Gololobova, Olesia, Liao, Zhaohao, Nyberg, Lyle H, Lima, Gabriela, Paniushkina, Liliia, Garcia-Contreras, Marta, Schonvisky, Kayla, Castell, Natalie, Stover, Mitchel, Guerrero-Martin, Selena, Richardson, Riley, Smith, Barbara, Machairaki, Vasiliki, Lai, Charles P, Izzi, Jessica M, Hutchinson, Eric K, Pate, Kelly AM, Witwer, Kenneth W
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: Wiley 2023
Online Access:https://hdl.handle.net/1721.1/147893

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