| Summary: | <jats:p>
Mucin glycoproteins are a major component that contributes to the complexity of the female reproductive tract (FRT). Group B
<jats:named-content content-type="genus-species">Streptococcus</jats:named-content>
(GBS) is present in the FRT of 25–30% of healthy women, but during pregnancy can ascend to the uterus to cause preterm birth and fetal infection
<jats:italic>in utero.</jats:italic>
Here we show that a prominent mucin found in the FRT, MUC5B, promotes host defense by inhibiting GBS interaction with epithelial cells found in the FRT and ascension from the vagina to the uterus
<jats:italic>in vivo</jats:italic>
.
</jats:p>
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