Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness
<jats:p>Long Covid has raised awareness of the potentially disabling chronic sequelae that afflicts patients after acute viral infection. Similar syndromes of post-infectious sequelae have also been observed after other viral infections such as dengue, but their true prevalence and functional...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023
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| Online Access: | https://hdl.handle.net/1721.1/147920 |
| _version_ | 1826190017676967936 |
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| author | Kalimuddin, Shirin Teh, Yii Ean Wee, Liang En Paintal, Shay Sasisekharan, Ram Low, Jenny G Sheth, Sujata K Ooi, Eng Eong |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Kalimuddin, Shirin Teh, Yii Ean Wee, Liang En Paintal, Shay Sasisekharan, Ram Low, Jenny G Sheth, Sujata K Ooi, Eng Eong |
| author_sort | Kalimuddin, Shirin |
| collection | MIT |
| description | <jats:p>Long Covid has raised awareness of the potentially disabling chronic sequelae that afflicts patients after acute viral infection. Similar syndromes of post-infectious sequelae have also been observed after other viral infections such as dengue, but their true prevalence and functional impact remain poorly defined. We prospectively enrolled 209 patients with acute dengue (n = 48; one with severe dengue) and other acute viral respiratory infections (ARI) (n = 161), and followed them up for chronic sequelae up to one year post-enrolment, prior to the onset of the Covid-19 pandemic. Baseline demographics and co-morbidities were balanced between both groups except for gender, with more males in the dengue cohort (63% vs 29%, p<0.001). Except for the first visit, data on symptoms were collected remotely using a purpose-built mobile phone application. Mental health outcomes were evaluated using the validated SF-12v2 Health Survey. Almost all patients (95.8% of dengue and 94.4% of ARI patients) experienced at least one symptom of fatigue, somnolence, headache, concentration impairment or memory impairment within the first week of enrolment. Amongst patients with at least 3-months of follow-up, 18.0% in the dengue cohort and 14.6% in the ARI cohort experienced persistent symptoms. The median month-3 SF-12v2 Mental Component Summary Score was lower in patients who remained symptomatic at 3 months and beyond, compared to those whose symptoms fully resolved (47.7 vs. 56.0, p<0.001), indicating that patients who self-reported persistence of symptoms also experienced functionally worse mental health. No statistically significant difference in age, gender distribution or hospitalisation status was observed between those with and without chronic sequelae. Our findings reveal an under-appreciated burden of post-infection chronic sequelae in dengue and ARI patients. They call for studies to define the pathophysiology of this condition, and determine the efficacy of both vaccines as well as antiviral drugs in preventing such sequelae.</jats:p> |
| first_indexed | 2024-09-23T08:33:45Z |
| format | Article |
| id | mit-1721.1/147920 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:33:45Z |
| publishDate | 2023 |
| publisher | Public Library of Science (PLoS) |
| record_format | dspace |
| spelling | mit-1721.1/1479202023-02-07T03:51:44Z Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness Kalimuddin, Shirin Teh, Yii Ean Wee, Liang En Paintal, Shay Sasisekharan, Ram Low, Jenny G Sheth, Sujata K Ooi, Eng Eong Massachusetts Institute of Technology. Department of Biological Engineering <jats:p>Long Covid has raised awareness of the potentially disabling chronic sequelae that afflicts patients after acute viral infection. Similar syndromes of post-infectious sequelae have also been observed after other viral infections such as dengue, but their true prevalence and functional impact remain poorly defined. We prospectively enrolled 209 patients with acute dengue (n = 48; one with severe dengue) and other acute viral respiratory infections (ARI) (n = 161), and followed them up for chronic sequelae up to one year post-enrolment, prior to the onset of the Covid-19 pandemic. Baseline demographics and co-morbidities were balanced between both groups except for gender, with more males in the dengue cohort (63% vs 29%, p<0.001). Except for the first visit, data on symptoms were collected remotely using a purpose-built mobile phone application. Mental health outcomes were evaluated using the validated SF-12v2 Health Survey. Almost all patients (95.8% of dengue and 94.4% of ARI patients) experienced at least one symptom of fatigue, somnolence, headache, concentration impairment or memory impairment within the first week of enrolment. Amongst patients with at least 3-months of follow-up, 18.0% in the dengue cohort and 14.6% in the ARI cohort experienced persistent symptoms. The median month-3 SF-12v2 Mental Component Summary Score was lower in patients who remained symptomatic at 3 months and beyond, compared to those whose symptoms fully resolved (47.7 vs. 56.0, p<0.001), indicating that patients who self-reported persistence of symptoms also experienced functionally worse mental health. No statistically significant difference in age, gender distribution or hospitalisation status was observed between those with and without chronic sequelae. Our findings reveal an under-appreciated burden of post-infection chronic sequelae in dengue and ARI patients. They call for studies to define the pathophysiology of this condition, and determine the efficacy of both vaccines as well as antiviral drugs in preventing such sequelae.</jats:p> 2023-02-06T19:59:56Z 2023-02-06T19:59:56Z 2022 2023-02-06T19:55:59Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/147920 Kalimuddin, Shirin, Teh, Yii Ean, Wee, Liang En, Paintal, Shay, Sasisekharan, Ram et al. 2022. "Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness." PLoS Neglected Tropical Diseases, 16 (8). en 10.1371/JOURNAL.PNTD.0010724 PLoS Neglected Tropical Diseases Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Public Library of Science (PLoS) PLoS |
| spellingShingle | Kalimuddin, Shirin Teh, Yii Ean Wee, Liang En Paintal, Shay Sasisekharan, Ram Low, Jenny G Sheth, Sujata K Ooi, Eng Eong Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness |
| title | Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness |
| title_full | Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness |
| title_fullStr | Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness |
| title_full_unstemmed | Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness |
| title_short | Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness |
| title_sort | chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness |
| url | https://hdl.handle.net/1721.1/147920 |
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