Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma

Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma

Inhibitors of the mitotic kinesin Kif11 are anti-mitotics that, unlike vinca alkaloids or taxanes, do not disrupt microtubules and are not neurotoxic. However, development of resistance has limited their clinical utility. While resistance to Kif11 inhibitors in other cell types is due to mechanisms...

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Bibliographic Details
Main Authors: Kenchappa, Rajappa S, Dovas, Athanassios, Argenziano, Michael G, Meyer, Christian T, Stopfer, Lauren E, Banu, Matei A, Pereira, Brianna, Griffith, Jessica, Mohammad, Afroz, Talele, Surabhi, Haddock, Ashley, Zarco, Natanael, Elmquist, William, White, Forest, Quaranta, Vito, Sims, Peter, Canoll, Peter, Rosenfeld, Steven S
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: Elsevier BV 2023
Online Access:https://hdl.handle.net/1721.1/147947

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