Actively Triggerable Metals via Liquid Metal Embrittlement for Biomedical Applications
Actively triggerable materials, which break down upon introduction of an exogenous stimulus, enable precise control over the lifetime of biomedical technologies, as well as adaptation to unforeseen circumstances, such as changes to an established treatment plan. Yet, most actively triggerable materi...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023
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| Online Access: | https://hdl.handle.net/1721.1/148044 |
| _version_ | 1826190844470755328 |
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| author | Feig, Vivian R Remlova, Eva Muller, Benjamin Kuosmanen, Johannes LP Lal, Nikhil Ginzburg, Anna Nan, Kewang Patel, Ashka Jebran, Ahmad Mujtaba Bantwal, Meghana Prabhu Fabian, Niora Ishida, Keiko Jenkins, Joshua Rosenboom, Jan‐Georg Park, Sanghyun Madani, Wiam Hayward, Alison Traverso, Giovanni |
| author2 | Massachusetts Institute of Technology. Department of Mechanical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Mechanical Engineering Feig, Vivian R Remlova, Eva Muller, Benjamin Kuosmanen, Johannes LP Lal, Nikhil Ginzburg, Anna Nan, Kewang Patel, Ashka Jebran, Ahmad Mujtaba Bantwal, Meghana Prabhu Fabian, Niora Ishida, Keiko Jenkins, Joshua Rosenboom, Jan‐Georg Park, Sanghyun Madani, Wiam Hayward, Alison Traverso, Giovanni |
| author_sort | Feig, Vivian R |
| collection | MIT |
| description | Actively triggerable materials, which break down upon introduction of an exogenous stimulus, enable precise control over the lifetime of biomedical technologies, as well as adaptation to unforeseen circumstances, such as changes to an established treatment plan. Yet, most actively triggerable materials are low-strength polymers and hydrogels with limited long-term durability. By contrast, metals possess advantageous functional properties, including high mechanical strength and conductivity, that are desirable across several applications within biomedicine. To realize actively triggerable metals, a mechanism called liquid metal embrittlement is leveraged, in which certain liquid metals penetrate the grain boundaries of certain solid metals and cause them to dramatically weaken or disintegrate. In this work, it is demonstrated that eutectic gallium indium (EGaIn), a biocompatible alloy of gallium, can be formulated to reproducibly trigger the breakdown of aluminum within different physiologically relevant environments. The breakdown behavior of aluminum after triggering can further be readily controlled by manipulating its grain structure. Finally, three possible use cases of biomedical devices constructed from actively triggerable metals are demonstrated. |
| first_indexed | 2024-09-23T08:46:12Z |
| format | Article |
| id | mit-1721.1/148044 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:46:12Z |
| publishDate | 2023 |
| publisher | Wiley |
| record_format | dspace |
| spelling | mit-1721.1/1480442023-02-15T03:47:52Z Actively Triggerable Metals via Liquid Metal Embrittlement for Biomedical Applications Feig, Vivian R Remlova, Eva Muller, Benjamin Kuosmanen, Johannes LP Lal, Nikhil Ginzburg, Anna Nan, Kewang Patel, Ashka Jebran, Ahmad Mujtaba Bantwal, Meghana Prabhu Fabian, Niora Ishida, Keiko Jenkins, Joshua Rosenboom, Jan‐Georg Park, Sanghyun Madani, Wiam Hayward, Alison Traverso, Giovanni Massachusetts Institute of Technology. Department of Mechanical Engineering Actively triggerable materials, which break down upon introduction of an exogenous stimulus, enable precise control over the lifetime of biomedical technologies, as well as adaptation to unforeseen circumstances, such as changes to an established treatment plan. Yet, most actively triggerable materials are low-strength polymers and hydrogels with limited long-term durability. By contrast, metals possess advantageous functional properties, including high mechanical strength and conductivity, that are desirable across several applications within biomedicine. To realize actively triggerable metals, a mechanism called liquid metal embrittlement is leveraged, in which certain liquid metals penetrate the grain boundaries of certain solid metals and cause them to dramatically weaken or disintegrate. In this work, it is demonstrated that eutectic gallium indium (EGaIn), a biocompatible alloy of gallium, can be formulated to reproducibly trigger the breakdown of aluminum within different physiologically relevant environments. The breakdown behavior of aluminum after triggering can further be readily controlled by manipulating its grain structure. Finally, three possible use cases of biomedical devices constructed from actively triggerable metals are demonstrated. 2023-02-14T16:37:55Z 2023-02-14T16:37:55Z 2022-11-02 2023-02-14T16:32:04Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/148044 Feig, Vivian R, Remlova, Eva, Muller, Benjamin, Kuosmanen, Johannes LP, Lal, Nikhil et al. 2022. "Actively Triggerable Metals via Liquid Metal Embrittlement for Biomedical Applications." Advanced Materials. en 10.1002/adma.202208227 Advanced Materials Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Wiley Wiley |
| spellingShingle | Feig, Vivian R Remlova, Eva Muller, Benjamin Kuosmanen, Johannes LP Lal, Nikhil Ginzburg, Anna Nan, Kewang Patel, Ashka Jebran, Ahmad Mujtaba Bantwal, Meghana Prabhu Fabian, Niora Ishida, Keiko Jenkins, Joshua Rosenboom, Jan‐Georg Park, Sanghyun Madani, Wiam Hayward, Alison Traverso, Giovanni Actively Triggerable Metals via Liquid Metal Embrittlement for Biomedical Applications |
| title | Actively Triggerable Metals via Liquid Metal Embrittlement for Biomedical Applications |
| title_full | Actively Triggerable Metals via Liquid Metal Embrittlement for Biomedical Applications |
| title_fullStr | Actively Triggerable Metals via Liquid Metal Embrittlement for Biomedical Applications |
| title_full_unstemmed | Actively Triggerable Metals via Liquid Metal Embrittlement for Biomedical Applications |
| title_short | Actively Triggerable Metals via Liquid Metal Embrittlement for Biomedical Applications |
| title_sort | actively triggerable metals via liquid metal embrittlement for biomedical applications |
| url | https://hdl.handle.net/1721.1/148044 |
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