Mobile zinc as a modulator of sensory perception
Mobile zinc is an abundant transition metal ion in the central nervous system, with pools of divalent zinc accumulating in regions of the brain engaged in sensory perception and memory formation. Here, we present essential tools that we developed to interrogate the role(s) of mobile zinc in these pr...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Wiley
2023
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| Online Access: | https://hdl.handle.net/1721.1/148047 |
| _version_ | 1811092662281830400 |
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| author | Goldberg, Jacob M Lippard, Stephen J |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Goldberg, Jacob M Lippard, Stephen J |
| author_sort | Goldberg, Jacob M |
| collection | MIT |
| description | Mobile zinc is an abundant transition metal ion in the central nervous system, with pools of divalent zinc accumulating in regions of the brain engaged in sensory perception and memory formation. Here, we present essential tools that we developed to interrogate the role(s) of mobile zinc in these processes. Most important are (a) fluorescent sensors that report the presence of mobile zinc and (b) fast, Zn-selective chelating agents for measuring zinc flux in animal tissue and live animals. The results of our studies, conducted in collaboration with neuroscientist experts, are presented for sensory organs involved in hearing, smell, vision, and learning and memory. A general principle emerging from these studies is that the function of mobile zinc in all cases appears to be downregulation of the amplitude of the response following overstimulation of the respective sensory organs. Possible consequences affecting human behavior are presented for future investigations in collaboration with interested behavioral scientists. |
| first_indexed | 2024-09-23T15:21:40Z |
| format | Article |
| id | mit-1721.1/148047 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T15:21:40Z |
| publishDate | 2023 |
| publisher | Wiley |
| record_format | dspace |
| spelling | mit-1721.1/1480472023-02-15T03:07:01Z Mobile zinc as a modulator of sensory perception Goldberg, Jacob M Lippard, Stephen J Massachusetts Institute of Technology. Department of Chemistry Mobile zinc is an abundant transition metal ion in the central nervous system, with pools of divalent zinc accumulating in regions of the brain engaged in sensory perception and memory formation. Here, we present essential tools that we developed to interrogate the role(s) of mobile zinc in these processes. Most important are (a) fluorescent sensors that report the presence of mobile zinc and (b) fast, Zn-selective chelating agents for measuring zinc flux in animal tissue and live animals. The results of our studies, conducted in collaboration with neuroscientist experts, are presented for sensory organs involved in hearing, smell, vision, and learning and memory. A general principle emerging from these studies is that the function of mobile zinc in all cases appears to be downregulation of the amplitude of the response following overstimulation of the respective sensory organs. Possible consequences affecting human behavior are presented for future investigations in collaboration with interested behavioral scientists. 2023-02-14T16:55:16Z 2023-02-14T16:55:16Z 2023-01 2023-02-14T16:50:51Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/148047 Goldberg, Jacob M and Lippard, Stephen J. 2023. "Mobile zinc as a modulator of sensory perception." FEBS Letters, 597 (1). en 10.1002/1873-3468.14544 FEBS Letters Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Wiley Wiley |
| spellingShingle | Goldberg, Jacob M Lippard, Stephen J Mobile zinc as a modulator of sensory perception |
| title | Mobile zinc as a modulator of sensory perception |
| title_full | Mobile zinc as a modulator of sensory perception |
| title_fullStr | Mobile zinc as a modulator of sensory perception |
| title_full_unstemmed | Mobile zinc as a modulator of sensory perception |
| title_short | Mobile zinc as a modulator of sensory perception |
| title_sort | mobile zinc as a modulator of sensory perception |
| url | https://hdl.handle.net/1721.1/148047 |
| work_keys_str_mv | AT goldbergjacobm mobilezincasamodulatorofsensoryperception AT lippardstephenj mobilezincasamodulatorofsensoryperception |