Nα-Methylation of arginine: Implications for cell-penetrating peptides

The field of cell-penetrating peptides is dominated by the use of oligomers of arginine residues. Octanol-water partitioning in the presence of an anionic lipid is a validated proxy for cell-penetrative efficacy. Here, we add one, two, or three N-methyl groups to Ac-Arg-NH2 and examine the effects o...

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Bibliographic Details
Main Authors: Calabretta, Lindsey O, Yang, Jinyi, Raines, Ronald T
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:English
Published: Wiley 2023
Online Access:https://hdl.handle.net/1721.1/148050

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