Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities
With increasing attention on the essential roles of the tumour microenvironment in recent years, the nervous system has emerged as a novel and crucial facilitator of cancer growth. In this Review, we describe the foundational, translational, and clinical advances illustrating how nerves contribute t...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2023
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| Online Access: | https://hdl.handle.net/1721.1/148200 |
| _version_ | 1826191950496137216 |
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| author | Shi, Diana D Guo, Jimmy A Hoffman, Hannah I Su, Jennifer Mino-Kenudson, Mari Barth, Jaimie L Schenkel, Jason M Loeffler, Jay S Shih, Helen A Hong, Theodore S Wo, Jennifer Y Aguirre, Andrew J Jacks, Tyler Zheng, Lei Wen, Patrick Y Wang, Timothy C Hwang, William L |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Shi, Diana D Guo, Jimmy A Hoffman, Hannah I Su, Jennifer Mino-Kenudson, Mari Barth, Jaimie L Schenkel, Jason M Loeffler, Jay S Shih, Helen A Hong, Theodore S Wo, Jennifer Y Aguirre, Andrew J Jacks, Tyler Zheng, Lei Wen, Patrick Y Wang, Timothy C Hwang, William L |
| author_sort | Shi, Diana D |
| collection | MIT |
| description | With increasing attention on the essential roles of the tumour microenvironment in recent years, the nervous system has emerged as a novel and crucial facilitator of cancer growth. In this Review, we describe the foundational, translational, and clinical advances illustrating how nerves contribute to tumour proliferation, stress adaptation, immunomodulation, metastasis, electrical hyperactivity and seizures, and neuropathic pain. Collectively, this expanding knowledge base reveals multiple therapeutic avenues for cancer neuroscience that warrant further exploration in clinical studies. We discuss the available clinical data, including ongoing trials investigating novel agents targeting the tumour-nerve axis, and the therapeutic potential for repurposing existing neuroactive drugs as an anti-cancer approach, particularly in combination with established treatment regimens. Lastly, we discuss the clinical challenges of these treatment strategies and highlight unanswered questions and future directions in the burgeoning field of cancer neuroscience. |
| first_indexed | 2024-09-23T09:03:53Z |
| format | Article |
| id | mit-1721.1/148200 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:03:53Z |
| publishDate | 2023 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1482002024-01-22T21:17:10Z Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities Shi, Diana D Guo, Jimmy A Hoffman, Hannah I Su, Jennifer Mino-Kenudson, Mari Barth, Jaimie L Schenkel, Jason M Loeffler, Jay S Shih, Helen A Hong, Theodore S Wo, Jennifer Y Aguirre, Andrew J Jacks, Tyler Zheng, Lei Wen, Patrick Y Wang, Timothy C Hwang, William L Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Harvard University--MIT Division of Health Sciences and Technology With increasing attention on the essential roles of the tumour microenvironment in recent years, the nervous system has emerged as a novel and crucial facilitator of cancer growth. In this Review, we describe the foundational, translational, and clinical advances illustrating how nerves contribute to tumour proliferation, stress adaptation, immunomodulation, metastasis, electrical hyperactivity and seizures, and neuropathic pain. Collectively, this expanding knowledge base reveals multiple therapeutic avenues for cancer neuroscience that warrant further exploration in clinical studies. We discuss the available clinical data, including ongoing trials investigating novel agents targeting the tumour-nerve axis, and the therapeutic potential for repurposing existing neuroactive drugs as an anti-cancer approach, particularly in combination with established treatment regimens. Lastly, we discuss the clinical challenges of these treatment strategies and highlight unanswered questions and future directions in the burgeoning field of cancer neuroscience. 2023-02-23T18:42:05Z 2023-02-23T18:42:05Z 2022 2023-02-23T18:24:24Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/148200 Shi, Diana D, Guo, Jimmy A, Hoffman, Hannah I, Su, Jennifer, Mino-Kenudson, Mari et al. 2022. "Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities." Lancet Oncology, 23 (2). en 10.1016/S1470-2045(21)00596-9 Lancet Oncology Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Shi, Diana D Guo, Jimmy A Hoffman, Hannah I Su, Jennifer Mino-Kenudson, Mari Barth, Jaimie L Schenkel, Jason M Loeffler, Jay S Shih, Helen A Hong, Theodore S Wo, Jennifer Y Aguirre, Andrew J Jacks, Tyler Zheng, Lei Wen, Patrick Y Wang, Timothy C Hwang, William L Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities |
| title | Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities |
| title_full | Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities |
| title_fullStr | Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities |
| title_full_unstemmed | Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities |
| title_short | Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities |
| title_sort | therapeutic avenues for cancer neuroscience translational frontiers and clinical opportunities |
| url | https://hdl.handle.net/1721.1/148200 |
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