7.342 Sweet Discoveries: Unraveling the Complex World of Sugars in Health and Disease, Fall 2014
Glycans, which are complex assemblies of sugars, are the most prevalent class of macromolecules, surpassing nucleic acids, proteins and lipids. Glycans are essential for life, as they are a required energy source, provide protection against cellular stresses and shape cellular structure. During this...
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| Format: | Learning Object |
| Language: | en-US |
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2023
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| Online Access: | https://hdl.handle.net/1721.1/148354 |
| _version_ | 1826216247092576256 |
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| author | Silverman, Julie M Walvoort, Maria |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Silverman, Julie M Walvoort, Maria |
| author_sort | Silverman, Julie M |
| collection | MIT |
| description | Glycans, which are complex assemblies of sugars, are the most prevalent class of macromolecules, surpassing nucleic acids, proteins and lipids. Glycans are essential for life, as they are a required energy source, provide protection against cellular stresses and shape cellular structure. During this course, we will explore the many roles glycans play in human health and disease. For example, we will learn about the healthy glycosylation patterns of many mammalian proteins and the dynamic changes that glycan structures undergo during early development and cancer metastasis, the influence of dietary carbohydrates on glycan metabolism, and the role of densely glycosylated proteins involved in HIV infectivity. Concurrently, we will learn about the chemical and biological techniques used to detect and visualize glycans by in vitro and whole-animal metabolic labeling approaches, how to profile protein-glycan interactions using high-throughput glycan arrays, and about the development of new carbohydrate-based therapeutics and vaccines to target HIV, influenza and bacterial pathogens. The course will focus on the primary research literature, and we will learn practical laboratory techniques, experimental design and how to interpret data and critique the conclusions offered by authors.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching. |
| first_indexed | 2024-09-23T16:44:39Z |
| format | Learning Object |
| id | mit-1721.1/148354 |
| institution | Massachusetts Institute of Technology |
| language | en-US |
| last_indexed | 2025-03-10T14:05:31Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | mit-1721.1/1483542025-02-26T20:59:11Z 7.342 Sweet Discoveries: Unraveling the Complex World of Sugars in Health and Disease, Fall 2014 Sweet Discoveries: Unraveling the Complex World of Sugars in Health and Disease Silverman, Julie M Walvoort, Maria Massachusetts Institute of Technology. Department of Biology Glycans glycobiology glycosylation patterns glycoproteins glycan metabolism glycosylated proteins protein-glycan interactions high-throughput glycan arrays O-glycans N-linked glycosylation glycosyl-amino acids Metabolic glycan labeling synthetic antigens 260204 Glycans, which are complex assemblies of sugars, are the most prevalent class of macromolecules, surpassing nucleic acids, proteins and lipids. Glycans are essential for life, as they are a required energy source, provide protection against cellular stresses and shape cellular structure. During this course, we will explore the many roles glycans play in human health and disease. For example, we will learn about the healthy glycosylation patterns of many mammalian proteins and the dynamic changes that glycan structures undergo during early development and cancer metastasis, the influence of dietary carbohydrates on glycan metabolism, and the role of densely glycosylated proteins involved in HIV infectivity. Concurrently, we will learn about the chemical and biological techniques used to detect and visualize glycans by in vitro and whole-animal metabolic labeling approaches, how to profile protein-glycan interactions using high-throughput glycan arrays, and about the development of new carbohydrate-based therapeutics and vaccines to target HIV, influenza and bacterial pathogens. The course will focus on the primary research literature, and we will learn practical laboratory techniques, experimental design and how to interpret data and critique the conclusions offered by authors.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching. 2023-03-06T17:25:07Z 2023-03-06T17:25:07Z 2014-12 2023-03-06T17:25:13Z Learning Object 7.342-Fall2014 7.342 IMSCP-MD5-2f56c4d573e14cb04657516ae490c29b https://hdl.handle.net/1721.1/148354 en-US This site (c) Massachusetts Institute of Technology 2023. Content within individual courses is (c) by the individual authors unless otherwise noted. 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| spellingShingle | Glycans glycobiology glycosylation patterns glycoproteins glycan metabolism glycosylated proteins protein-glycan interactions high-throughput glycan arrays O-glycans N-linked glycosylation glycosyl-amino acids Metabolic glycan labeling synthetic antigens 260204 Silverman, Julie M Walvoort, Maria 7.342 Sweet Discoveries: Unraveling the Complex World of Sugars in Health and Disease, Fall 2014 |
| title | 7.342 Sweet Discoveries: Unraveling the Complex World of Sugars in Health and Disease, Fall 2014 |
| title_full | 7.342 Sweet Discoveries: Unraveling the Complex World of Sugars in Health and Disease, Fall 2014 |
| title_fullStr | 7.342 Sweet Discoveries: Unraveling the Complex World of Sugars in Health and Disease, Fall 2014 |
| title_full_unstemmed | 7.342 Sweet Discoveries: Unraveling the Complex World of Sugars in Health and Disease, Fall 2014 |
| title_short | 7.342 Sweet Discoveries: Unraveling the Complex World of Sugars in Health and Disease, Fall 2014 |
| title_sort | 7 342 sweet discoveries unraveling the complex world of sugars in health and disease fall 2014 |
| topic | Glycans glycobiology glycosylation patterns glycoproteins glycan metabolism glycosylated proteins protein-glycan interactions high-throughput glycan arrays O-glycans N-linked glycosylation glycosyl-amino acids Metabolic glycan labeling synthetic antigens 260204 |
| url | https://hdl.handle.net/1721.1/148354 |
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