Motility of Different Gastric Helicobacter spp.
<i>Helicobacter</i> spp., including the well-known human gastric pathogen <i>H. pylori</i>, can cause gastric diseases in humans and other mammals. They are Gram-negative bacteria that colonize the gastric epithelium and use their multiple flagella to move across the protecti...
| Main Authors: | , , , , , |
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| Format: | Article |
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Multidisciplinary Digital Publishing Institute
2023
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| Online Access: | https://hdl.handle.net/1721.1/148470 |
| _version_ | 1811083206011650048 |
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| author | Bansil, Rama Constantino, Maira A. Su-Arcaro, Clover Liao, Wentian Shen, Zeli Fox, James G. |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Bansil, Rama Constantino, Maira A. Su-Arcaro, Clover Liao, Wentian Shen, Zeli Fox, James G. |
| author_sort | Bansil, Rama |
| collection | MIT |
| description | <i>Helicobacter</i> spp., including the well-known human gastric pathogen <i>H. pylori</i>, can cause gastric diseases in humans and other mammals. They are Gram-negative bacteria that colonize the gastric epithelium and use their multiple flagella to move across the protective gastric mucus layer. The flagella of different <i>Helicobacter</i> spp. vary in their location and number. This review focuses on the swimming characteristics of different species with different flagellar architectures and cell shapes. All <i>Helicobacter</i> spp. use a run-reverse-reorient mechanism to swim in aqueous solutions, as well as in gastric mucin. Comparisons of different strains and mutants of <i>H. pylori</i> varying in cell shape and the number of flagella show that their swimming speed increases with an increasing number of flagella and is somewhat enhanced with a helical cell body shape. The swimming mechanism of <i>H. suis</i>, which has bipolar flagella, is more complex than that of unipolar <i>H. pylori. H. suis</i> exhibits multiple modes of flagellar orientation while swimming. The pH-dependent viscosity and gelation of gastric mucin significantly impact the motility of <i>Helicobacter</i> spp. In the absence of urea, these bacteria do not swim in mucin gel at pH < 4, even though their flagellar bundle rotates. |
| first_indexed | 2024-09-23T12:28:25Z |
| format | Article |
| id | mit-1721.1/148470 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T12:28:25Z |
| publishDate | 2023 |
| publisher | Multidisciplinary Digital Publishing Institute |
| record_format | dspace |
| spelling | mit-1721.1/1484702024-01-12T21:20:35Z Motility of Different Gastric Helicobacter spp. Bansil, Rama Constantino, Maira A. Su-Arcaro, Clover Liao, Wentian Shen, Zeli Fox, James G. Massachusetts Institute of Technology. Department of Biological Engineering Picower Institute for Learning and Memory <i>Helicobacter</i> spp., including the well-known human gastric pathogen <i>H. pylori</i>, can cause gastric diseases in humans and other mammals. They are Gram-negative bacteria that colonize the gastric epithelium and use their multiple flagella to move across the protective gastric mucus layer. The flagella of different <i>Helicobacter</i> spp. vary in their location and number. This review focuses on the swimming characteristics of different species with different flagellar architectures and cell shapes. All <i>Helicobacter</i> spp. use a run-reverse-reorient mechanism to swim in aqueous solutions, as well as in gastric mucin. Comparisons of different strains and mutants of <i>H. pylori</i> varying in cell shape and the number of flagella show that their swimming speed increases with an increasing number of flagella and is somewhat enhanced with a helical cell body shape. The swimming mechanism of <i>H. suis</i>, which has bipolar flagella, is more complex than that of unipolar <i>H. pylori. H. suis</i> exhibits multiple modes of flagellar orientation while swimming. The pH-dependent viscosity and gelation of gastric mucin significantly impact the motility of <i>Helicobacter</i> spp. In the absence of urea, these bacteria do not swim in mucin gel at pH < 4, even though their flagellar bundle rotates. 2023-03-10T18:25:17Z 2023-03-10T18:25:17Z 2023-03-01 2023-03-10T14:02:01Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/148470 Microorganisms 11 (3): 634 (2023) PUBLISHER_CC http://dx.doi.org/10.3390/microorganisms11030634 Creative Commons Attribution https://creativecommons.org/licenses/by/4.0/ application/pdf Multidisciplinary Digital Publishing Institute Multidisciplinary Digital Publishing Institute |
| spellingShingle | Bansil, Rama Constantino, Maira A. Su-Arcaro, Clover Liao, Wentian Shen, Zeli Fox, James G. Motility of Different Gastric Helicobacter spp. |
| title | Motility of Different Gastric Helicobacter spp. |
| title_full | Motility of Different Gastric Helicobacter spp. |
| title_fullStr | Motility of Different Gastric Helicobacter spp. |
| title_full_unstemmed | Motility of Different Gastric Helicobacter spp. |
| title_short | Motility of Different Gastric Helicobacter spp. |
| title_sort | motility of different gastric helicobacter spp |
| url | https://hdl.handle.net/1721.1/148470 |
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