Temperature-Responsive Bottlebrush Polymers Deliver a Stress-Regulating Agent <i>In Vivo</i> for Prolonged Plant Heat Stress Mitigation
Anticipated increases in the frequency and intensity of extreme temperatures will damage crops. Methods that efficiently deliver stress-regulating agents to crops can mitigate these effects. Here, we describe high aspect ratio polymer bottlebrushes for temperature-controlled agent delivery in plants...
| Main Authors: | , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society (ACS)
2023
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| Online Access: | https://hdl.handle.net/1721.1/148609 |
| _version_ | 1826208436729151488 |
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| author | Zhang, Yilin Fu, Liye Martinez, Michael R Sun, Hui Nava, Valeria Yan, Jiajun Ristroph, Kurt Averick, Saadyah E Marelli, Benedetto Giraldo, Juan Pablo Matyjaszewski, Krzysztof Tilton, Robert D Lowry, Gregory V |
| author2 | Massachusetts Institute of Technology. Department of Civil and Environmental Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Civil and Environmental Engineering Zhang, Yilin Fu, Liye Martinez, Michael R Sun, Hui Nava, Valeria Yan, Jiajun Ristroph, Kurt Averick, Saadyah E Marelli, Benedetto Giraldo, Juan Pablo Matyjaszewski, Krzysztof Tilton, Robert D Lowry, Gregory V |
| author_sort | Zhang, Yilin |
| collection | MIT |
| description | Anticipated increases in the frequency and intensity of extreme temperatures will damage crops. Methods that efficiently deliver stress-regulating agents to crops can mitigate these effects. Here, we describe high aspect ratio polymer bottlebrushes for temperature-controlled agent delivery in plants. The foliar-applied bottlebrush polymers had near complete uptake into the leaf and resided in both the apoplastic regions of the leaf mesophyll and in cells surrounding the vasculature. Elevated temperature enhanced the in vivo release of spermidine (a stress-regulating agent) from the bottlebrushes, promoting tomato plant (Solanum lycopersicum) photosynthesis under heat and light stress. The bottlebrushes continued to provide protection against heat stress for at least 15 days after foliar application, whereas free spermidine did not. About 30% of the ∼80 nm short and ∼300 nm long bottlebrushes entered the phloem and moved to other plant organs, enabling heat-activated release of plant protection agents in phloem. These results indicate the ability of the polymer bottlebrushes to release encapsulated stress relief agents when triggered by heat to provide long-term protection to plants and the potential to manage plant phloem pathogens. Overall, this temperature-responsive delivery platform provides a new tool for protecting plants against climate-induced damage and yield loss. |
| first_indexed | 2024-09-23T14:05:44Z |
| format | Article |
| id | mit-1721.1/148609 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T14:05:44Z |
| publishDate | 2023 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/1486092024-01-22T18:15:56Z Temperature-Responsive Bottlebrush Polymers Deliver a Stress-Regulating Agent <i>In Vivo</i> for Prolonged Plant Heat Stress Mitigation Zhang, Yilin Fu, Liye Martinez, Michael R Sun, Hui Nava, Valeria Yan, Jiajun Ristroph, Kurt Averick, Saadyah E Marelli, Benedetto Giraldo, Juan Pablo Matyjaszewski, Krzysztof Tilton, Robert D Lowry, Gregory V Massachusetts Institute of Technology. Department of Civil and Environmental Engineering Anticipated increases in the frequency and intensity of extreme temperatures will damage crops. Methods that efficiently deliver stress-regulating agents to crops can mitigate these effects. Here, we describe high aspect ratio polymer bottlebrushes for temperature-controlled agent delivery in plants. The foliar-applied bottlebrush polymers had near complete uptake into the leaf and resided in both the apoplastic regions of the leaf mesophyll and in cells surrounding the vasculature. Elevated temperature enhanced the in vivo release of spermidine (a stress-regulating agent) from the bottlebrushes, promoting tomato plant (Solanum lycopersicum) photosynthesis under heat and light stress. The bottlebrushes continued to provide protection against heat stress for at least 15 days after foliar application, whereas free spermidine did not. About 30% of the ∼80 nm short and ∼300 nm long bottlebrushes entered the phloem and moved to other plant organs, enabling heat-activated release of plant protection agents in phloem. These results indicate the ability of the polymer bottlebrushes to release encapsulated stress relief agents when triggered by heat to provide long-term protection to plants and the potential to manage plant phloem pathogens. Overall, this temperature-responsive delivery platform provides a new tool for protecting plants against climate-induced damage and yield loss. 2023-03-17T17:45:48Z 2023-03-17T17:45:48Z 2023-02-27 2023-03-17T17:33:19Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/148609 Zhang, Yilin, Fu, Liye, Martinez, Michael R, Sun, Hui, Nava, Valeria et al. 2023. "Temperature-Responsive Bottlebrush Polymers Deliver a Stress-Regulating Agent <i>In Vivo</i> for Prolonged Plant Heat Stress Mitigation." ACS Sustainable Chemistry & Engineering, 11 (8). en 10.1021/acssuschemeng.2c06461 ACS Sustainable Chemistry & Engineering Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf American Chemical Society (ACS) ACS |
| spellingShingle | Zhang, Yilin Fu, Liye Martinez, Michael R Sun, Hui Nava, Valeria Yan, Jiajun Ristroph, Kurt Averick, Saadyah E Marelli, Benedetto Giraldo, Juan Pablo Matyjaszewski, Krzysztof Tilton, Robert D Lowry, Gregory V Temperature-Responsive Bottlebrush Polymers Deliver a Stress-Regulating Agent <i>In Vivo</i> for Prolonged Plant Heat Stress Mitigation |
| title | Temperature-Responsive Bottlebrush Polymers Deliver a Stress-Regulating Agent <i>In Vivo</i> for Prolonged Plant Heat Stress Mitigation |
| title_full | Temperature-Responsive Bottlebrush Polymers Deliver a Stress-Regulating Agent <i>In Vivo</i> for Prolonged Plant Heat Stress Mitigation |
| title_fullStr | Temperature-Responsive Bottlebrush Polymers Deliver a Stress-Regulating Agent <i>In Vivo</i> for Prolonged Plant Heat Stress Mitigation |
| title_full_unstemmed | Temperature-Responsive Bottlebrush Polymers Deliver a Stress-Regulating Agent <i>In Vivo</i> for Prolonged Plant Heat Stress Mitigation |
| title_short | Temperature-Responsive Bottlebrush Polymers Deliver a Stress-Regulating Agent <i>In Vivo</i> for Prolonged Plant Heat Stress Mitigation |
| title_sort | temperature responsive bottlebrush polymers deliver a stress regulating agent i in vivo i for prolonged plant heat stress mitigation |
| url | https://hdl.handle.net/1721.1/148609 |
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