Deep brain stimulation in the subthalamic nucleus for Parkinson’s disease can restore dynamics of striatal networks
<jats:title>Significance</jats:title> <jats:p>Deep brain stimulation (DBS) in the subthalamic nucleus (STN) is highly effective for treating the motor symptoms of Parkinson’s disease (PD). However, the neural mechanisms by which DBS acts are unknown. PD symptoms are tied...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Proceedings of the National Academy of Sciences
2023
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| Online Access: | https://hdl.handle.net/1721.1/148702 |
| _version_ | 1811095412542537728 |
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| author | Adam, Elie M Brown, Emery N Kopell, Nancy McCarthy, Michelle M |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Adam, Elie M Brown, Emery N Kopell, Nancy McCarthy, Michelle M |
| author_sort | Adam, Elie M |
| collection | MIT |
| description | <jats:title>Significance</jats:title>
<jats:p>Deep brain stimulation (DBS) in the subthalamic nucleus (STN) is highly effective for treating the motor symptoms of Parkinson’s disease (PD). However, the neural mechanisms by which DBS acts are unknown. PD symptoms are tied to altered brain rhythms in basal ganglia (BG) and particularly the striatum. We develop a biophysical model of a BG neural pathway and show how beta oscillations can emerge throughout BG in PD. We then establish a mechanism by which DBS in STN can interrupt these abnormal rhythms and restore the brain’s capability to produce and regulate normal rhythms lost with dopamine depletion. Our research suggests mechanisms to leverage striatal gamma and theta oscillations to counter aberrant dynamics and enhance the therapeutic effects of DBS.</jats:p> |
| first_indexed | 2024-09-23T16:16:21Z |
| format | Article |
| id | mit-1721.1/148702 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:16:21Z |
| publishDate | 2023 |
| publisher | Proceedings of the National Academy of Sciences |
| record_format | dspace |
| spelling | mit-1721.1/1487022023-03-25T03:02:57Z Deep brain stimulation in the subthalamic nucleus for Parkinson’s disease can restore dynamics of striatal networks Adam, Elie M Brown, Emery N Kopell, Nancy McCarthy, Michelle M Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences <jats:title>Significance</jats:title> <jats:p>Deep brain stimulation (DBS) in the subthalamic nucleus (STN) is highly effective for treating the motor symptoms of Parkinson’s disease (PD). However, the neural mechanisms by which DBS acts are unknown. PD symptoms are tied to altered brain rhythms in basal ganglia (BG) and particularly the striatum. We develop a biophysical model of a BG neural pathway and show how beta oscillations can emerge throughout BG in PD. We then establish a mechanism by which DBS in STN can interrupt these abnormal rhythms and restore the brain’s capability to produce and regulate normal rhythms lost with dopamine depletion. Our research suggests mechanisms to leverage striatal gamma and theta oscillations to counter aberrant dynamics and enhance the therapeutic effects of DBS.</jats:p> 2023-03-24T16:35:03Z 2023-03-24T16:35:03Z 2022 2023-03-24T15:59:38Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/148702 Adam, Elie M, Brown, Emery N, Kopell, Nancy and McCarthy, Michelle M. 2022. "Deep brain stimulation in the subthalamic nucleus for Parkinson’s disease can restore dynamics of striatal networks." Proceedings of the National Academy of Sciences of the United States of America, 119 (19). en 10.1073/PNAS.2120808119 Proceedings of the National Academy of Sciences of the United States of America Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Proceedings of the National Academy of Sciences PNAS |
| spellingShingle | Adam, Elie M Brown, Emery N Kopell, Nancy McCarthy, Michelle M Deep brain stimulation in the subthalamic nucleus for Parkinson’s disease can restore dynamics of striatal networks |
| title | Deep brain stimulation in the subthalamic nucleus for Parkinson’s disease can restore dynamics of striatal networks |
| title_full | Deep brain stimulation in the subthalamic nucleus for Parkinson’s disease can restore dynamics of striatal networks |
| title_fullStr | Deep brain stimulation in the subthalamic nucleus for Parkinson’s disease can restore dynamics of striatal networks |
| title_full_unstemmed | Deep brain stimulation in the subthalamic nucleus for Parkinson’s disease can restore dynamics of striatal networks |
| title_short | Deep brain stimulation in the subthalamic nucleus for Parkinson’s disease can restore dynamics of striatal networks |
| title_sort | deep brain stimulation in the subthalamic nucleus for parkinson s disease can restore dynamics of striatal networks |
| url | https://hdl.handle.net/1721.1/148702 |
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