Diverse states and stimuli tune olfactory receptor expression levels to modulate food-seeking behavior
<jats:p>Animals must weigh competing needs and states to generate adaptive behavioral responses to the environment. Sensorimotor circuits are thus tasked with integrating diverse external and internal cues relevant to these needs to generate context-appropriate behaviors. However, the mechanis...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications, Ltd
2023
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| Online Access: | https://hdl.handle.net/1721.1/148795 |
| _version_ | 1826189177982550016 |
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| author | McLachlan, Ian G Kramer, Talya S Dua, Malvika DiLoreto, Elizabeth M Gomes, Matthew A Dag, Ugur Srinivasan, Jagan Flavell, Steven W |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences McLachlan, Ian G Kramer, Talya S Dua, Malvika DiLoreto, Elizabeth M Gomes, Matthew A Dag, Ugur Srinivasan, Jagan Flavell, Steven W |
| author_sort | McLachlan, Ian G |
| collection | MIT |
| description | <jats:p>Animals must weigh competing needs and states to generate adaptive behavioral responses to the environment. Sensorimotor circuits are thus tasked with integrating diverse external and internal cues relevant to these needs to generate context-appropriate behaviors. However, the mechanisms that underlie this integration are largely unknown. Here, we show that a wide range of states and stimuli converge upon a single <jats:italic>Caenorhabditis elegans</jats:italic> olfactory neuron to modulate food-seeking behavior. Using an unbiased ribotagging approach, we find that the expression of olfactory receptor genes in the AWA olfactory neuron is influenced by a wide array of states and stimuli, including feeding state, physiological stress, and recent sensory cues. We identify odorants that activate these state-dependent olfactory receptors and show that altered expression of these receptors influences food-seeking and foraging. Further, we dissect the molecular and neural circuit pathways through which external sensory information and internal nutritional state are integrated by AWA. This reveals a modular organization in which sensory and state-related signals arising from different cell types in the body converge on AWA and independently control chemoreceptor expression. The synthesis of these signals by AWA allows animals to generate sensorimotor responses that reflect the animal’s overall state. Our findings suggest a general model in which sensory- and state-dependent transcriptional changes at the sensory periphery modulate animals’ sensorimotor responses to meet their ongoing needs and states.</jats:p> |
| first_indexed | 2024-09-23T08:10:44Z |
| format | Article |
| id | mit-1721.1/148795 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:10:44Z |
| publishDate | 2023 |
| publisher | eLife Sciences Publications, Ltd |
| record_format | dspace |
| spelling | mit-1721.1/1487952023-03-28T03:51:10Z Diverse states and stimuli tune olfactory receptor expression levels to modulate food-seeking behavior McLachlan, Ian G Kramer, Talya S Dua, Malvika DiLoreto, Elizabeth M Gomes, Matthew A Dag, Ugur Srinivasan, Jagan Flavell, Steven W Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences <jats:p>Animals must weigh competing needs and states to generate adaptive behavioral responses to the environment. Sensorimotor circuits are thus tasked with integrating diverse external and internal cues relevant to these needs to generate context-appropriate behaviors. However, the mechanisms that underlie this integration are largely unknown. Here, we show that a wide range of states and stimuli converge upon a single <jats:italic>Caenorhabditis elegans</jats:italic> olfactory neuron to modulate food-seeking behavior. Using an unbiased ribotagging approach, we find that the expression of olfactory receptor genes in the AWA olfactory neuron is influenced by a wide array of states and stimuli, including feeding state, physiological stress, and recent sensory cues. We identify odorants that activate these state-dependent olfactory receptors and show that altered expression of these receptors influences food-seeking and foraging. Further, we dissect the molecular and neural circuit pathways through which external sensory information and internal nutritional state are integrated by AWA. This reveals a modular organization in which sensory and state-related signals arising from different cell types in the body converge on AWA and independently control chemoreceptor expression. The synthesis of these signals by AWA allows animals to generate sensorimotor responses that reflect the animal’s overall state. Our findings suggest a general model in which sensory- and state-dependent transcriptional changes at the sensory periphery modulate animals’ sensorimotor responses to meet their ongoing needs and states.</jats:p> 2023-03-27T18:09:14Z 2023-03-27T18:09:14Z 2022 2023-03-27T18:01:07Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/148795 McLachlan, Ian G, Kramer, Talya S, Dua, Malvika, DiLoreto, Elizabeth M, Gomes, Matthew A et al. 2022. "Diverse states and stimuli tune olfactory receptor expression levels to modulate food-seeking behavior." eLife, 11. en 10.7554/ELIFE.79557 eLife Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf eLife Sciences Publications, Ltd eLife |
| spellingShingle | McLachlan, Ian G Kramer, Talya S Dua, Malvika DiLoreto, Elizabeth M Gomes, Matthew A Dag, Ugur Srinivasan, Jagan Flavell, Steven W Diverse states and stimuli tune olfactory receptor expression levels to modulate food-seeking behavior |
| title | Diverse states and stimuli tune olfactory receptor expression levels to modulate food-seeking behavior |
| title_full | Diverse states and stimuli tune olfactory receptor expression levels to modulate food-seeking behavior |
| title_fullStr | Diverse states and stimuli tune olfactory receptor expression levels to modulate food-seeking behavior |
| title_full_unstemmed | Diverse states and stimuli tune olfactory receptor expression levels to modulate food-seeking behavior |
| title_short | Diverse states and stimuli tune olfactory receptor expression levels to modulate food-seeking behavior |
| title_sort | diverse states and stimuli tune olfactory receptor expression levels to modulate food seeking behavior |
| url | https://hdl.handle.net/1721.1/148795 |
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