Highly Sensitive Electrochemical Non-Enzymatic Uric Acid Sensor Based on Cobalt Oxide Puffy Balls-like Nanostructure
Early-stage uric acid (UA) abnormality detection is crucial for a healthy human. With the evolution of nanoscience, metal oxide nanostructure-based sensors have become a potential candidate for health monitoring due to their low-cost, easy-to-handle, and portability. Herein, we demonstrate the synth...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
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Multidisciplinary Digital Publishing Institute
2023
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| Online Access: | https://hdl.handle.net/1721.1/148808 |
| _version_ | 1826196809894068224 |
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| author | Nagal, Vandana Masrat, Sakeena Khan, Marya Alam, Shamshad Ahmad, Akil Alshammari, Mohammed B. Bhat, Kiesar Sideeq Novikov, Sergey M. Mishra, Prabhash Khosla, Ajit Ahmad, Rafiq |
| author2 | Singapore-MIT Alliance in Research and Technology (SMART) |
| author_facet | Singapore-MIT Alliance in Research and Technology (SMART) Nagal, Vandana Masrat, Sakeena Khan, Marya Alam, Shamshad Ahmad, Akil Alshammari, Mohammed B. Bhat, Kiesar Sideeq Novikov, Sergey M. Mishra, Prabhash Khosla, Ajit Ahmad, Rafiq |
| author_sort | Nagal, Vandana |
| collection | MIT |
| description | Early-stage uric acid (UA) abnormality detection is crucial for a healthy human. With the evolution of nanoscience, metal oxide nanostructure-based sensors have become a potential candidate for health monitoring due to their low-cost, easy-to-handle, and portability. Herein, we demonstrate the synthesis of puffy balls-like cobalt oxide nanostructure using a hydrothermal method and utilize them to modify the working electrode for non-enzymatic electrochemical sensor fabrication. The non-enzymatic electrochemical sensor was utilized for UA determination using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The puffy balls-shaped cobalt oxide nanostructure-modified glassy carbon (GC) electrode exhibited excellent electro-catalytic activity during UA detection. Interestingly, when we compared the sensitivity of non-enzymatic electrochemical UA sensors, the DPV technique resulted in high sensitivity (2158 µA/mM.cm<sup>2</sup>) compared to the CV technique (sensitivity = 307 µA/mM.cm<sup>2</sup>). The developed non-enzymatic electrochemical UA sensor showed good selectivity, stability, reproducibility, and applicability in the human serum. Moreover, this study indicates that the puffy balls-shaped cobalt oxide nanostructure can be utilized as electrode material for designing (bio)sensors to detect a specific analyte. |
| first_indexed | 2024-09-23T10:38:20Z |
| format | Article |
| id | mit-1721.1/148808 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T10:38:20Z |
| publishDate | 2023 |
| publisher | Multidisciplinary Digital Publishing Institute |
| record_format | dspace |
| spelling | mit-1721.1/1488082024-01-19T18:50:09Z Highly Sensitive Electrochemical Non-Enzymatic Uric Acid Sensor Based on Cobalt Oxide Puffy Balls-like Nanostructure Nagal, Vandana Masrat, Sakeena Khan, Marya Alam, Shamshad Ahmad, Akil Alshammari, Mohammed B. Bhat, Kiesar Sideeq Novikov, Sergey M. Mishra, Prabhash Khosla, Ajit Ahmad, Rafiq Singapore-MIT Alliance in Research and Technology (SMART) Early-stage uric acid (UA) abnormality detection is crucial for a healthy human. With the evolution of nanoscience, metal oxide nanostructure-based sensors have become a potential candidate for health monitoring due to their low-cost, easy-to-handle, and portability. Herein, we demonstrate the synthesis of puffy balls-like cobalt oxide nanostructure using a hydrothermal method and utilize them to modify the working electrode for non-enzymatic electrochemical sensor fabrication. The non-enzymatic electrochemical sensor was utilized for UA determination using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The puffy balls-shaped cobalt oxide nanostructure-modified glassy carbon (GC) electrode exhibited excellent electro-catalytic activity during UA detection. Interestingly, when we compared the sensitivity of non-enzymatic electrochemical UA sensors, the DPV technique resulted in high sensitivity (2158 µA/mM.cm<sup>2</sup>) compared to the CV technique (sensitivity = 307 µA/mM.cm<sup>2</sup>). The developed non-enzymatic electrochemical UA sensor showed good selectivity, stability, reproducibility, and applicability in the human serum. Moreover, this study indicates that the puffy balls-shaped cobalt oxide nanostructure can be utilized as electrode material for designing (bio)sensors to detect a specific analyte. 2023-03-28T13:48:06Z 2023-03-28T13:48:06Z 2023-03-12 2023-03-28T12:55:43Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/148808 Biosensors 13 (3): 375 (2023) PUBLISHER_CC http://dx.doi.org/10.3390/bios13030375 Creative Commons Attribution https://creativecommons.org/licenses/by/4.0/ application/pdf Multidisciplinary Digital Publishing Institute Multidisciplinary Digital Publishing Institute |
| spellingShingle | Nagal, Vandana Masrat, Sakeena Khan, Marya Alam, Shamshad Ahmad, Akil Alshammari, Mohammed B. Bhat, Kiesar Sideeq Novikov, Sergey M. Mishra, Prabhash Khosla, Ajit Ahmad, Rafiq Highly Sensitive Electrochemical Non-Enzymatic Uric Acid Sensor Based on Cobalt Oxide Puffy Balls-like Nanostructure |
| title | Highly Sensitive Electrochemical Non-Enzymatic Uric Acid Sensor Based on Cobalt Oxide Puffy Balls-like Nanostructure |
| title_full | Highly Sensitive Electrochemical Non-Enzymatic Uric Acid Sensor Based on Cobalt Oxide Puffy Balls-like Nanostructure |
| title_fullStr | Highly Sensitive Electrochemical Non-Enzymatic Uric Acid Sensor Based on Cobalt Oxide Puffy Balls-like Nanostructure |
| title_full_unstemmed | Highly Sensitive Electrochemical Non-Enzymatic Uric Acid Sensor Based on Cobalt Oxide Puffy Balls-like Nanostructure |
| title_short | Highly Sensitive Electrochemical Non-Enzymatic Uric Acid Sensor Based on Cobalt Oxide Puffy Balls-like Nanostructure |
| title_sort | highly sensitive electrochemical non enzymatic uric acid sensor based on cobalt oxide puffy balls like nanostructure |
| url | https://hdl.handle.net/1721.1/148808 |
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