Qualitative Simulation in Medical Physiology: A Progress Report
This progress report describes the current status of the application of the QSIM qualitative simulation representation and algorithm to mechanisms drawn from medical physiology. QSIM takes a qualitative description of the structure of a mechanism and produces and qualitative description of its behav...
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| Published: |
2023
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| Online Access: | https://hdl.handle.net/1721.1/149089 |
| _version_ | 1826211783728168960 |
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| author | Kuipers, Benjamin |
| author_facet | Kuipers, Benjamin |
| author_sort | Kuipers, Benjamin |
| collection | MIT |
| description | This progress report describes the current status of the application of the QSIM qualitative simulation representation and algorithm to mechanisms drawn from medical physiology. QSIM takes a qualitative description of the structure of a mechanism and produces and qualitative description of its behavior. Here we apply it to a set of different, medically realistic examples, to represent the following kinds of knowledge: 1) Physiology: qualitative simulation handles the response of normally-functioning mechanisms for salt and water balance to a variety of different environmental perturbations. 2) Pathophysiology: local changes to the structure describing a normal mechanism produces a structure that accurately describes the pathophysiology of a set of diseases. 3) Abstraction: the knowledge of the complexity of human physiology can only be handled by organizing it hierarchically. A hierarchy according to the temporal scale of equilibrium processes appears to be promising. 4) Cardiology: a complex structure describing maintenance of heart rate and blood pressure was adequately constructed during a short meeting with a set of computationally sophisticated physicians. 5) Future Directions: we can outline some of the representation barriers in the way of capturing a broader range of medical knowledge. |
| first_indexed | 2024-09-23T15:11:21Z |
| id | mit-1721.1/149089 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T15:11:21Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | mit-1721.1/1490892023-03-30T03:16:52Z Qualitative Simulation in Medical Physiology: A Progress Report Kuipers, Benjamin This progress report describes the current status of the application of the QSIM qualitative simulation representation and algorithm to mechanisms drawn from medical physiology. QSIM takes a qualitative description of the structure of a mechanism and produces and qualitative description of its behavior. Here we apply it to a set of different, medically realistic examples, to represent the following kinds of knowledge: 1) Physiology: qualitative simulation handles the response of normally-functioning mechanisms for salt and water balance to a variety of different environmental perturbations. 2) Pathophysiology: local changes to the structure describing a normal mechanism produces a structure that accurately describes the pathophysiology of a set of diseases. 3) Abstraction: the knowledge of the complexity of human physiology can only be handled by organizing it hierarchically. A hierarchy according to the temporal scale of equilibrium processes appears to be promising. 4) Cardiology: a complex structure describing maintenance of heart rate and blood pressure was adequately constructed during a short meeting with a set of computationally sophisticated physicians. 5) Future Directions: we can outline some of the representation barriers in the way of capturing a broader range of medical knowledge. 2023-03-29T14:26:16Z 2023-03-29T14:26:16Z 1985-06 https://hdl.handle.net/1721.1/149089 MIT-LCS-TM-280 application/pdf |
| spellingShingle | Kuipers, Benjamin Qualitative Simulation in Medical Physiology: A Progress Report |
| title | Qualitative Simulation in Medical Physiology: A Progress Report |
| title_full | Qualitative Simulation in Medical Physiology: A Progress Report |
| title_fullStr | Qualitative Simulation in Medical Physiology: A Progress Report |
| title_full_unstemmed | Qualitative Simulation in Medical Physiology: A Progress Report |
| title_short | Qualitative Simulation in Medical Physiology: A Progress Report |
| title_sort | qualitative simulation in medical physiology a progress report |
| url | https://hdl.handle.net/1721.1/149089 |
| work_keys_str_mv | AT kuipersbenjamin qualitativesimulationinmedicalphysiologyaprogressreport |