Reduced variability of bursting activity during working memory
<jats:title>Abstract</jats:title><jats:p>Working memories have long been thought to be maintained by persistent spiking. However, mounting evidence from multiple-electrode recording (and single-trial analyses) shows that the underlying spiking is better characterized by intermitten...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Springer Science and Business Media LLC
2023
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| Online Access: | https://hdl.handle.net/1721.1/150019 |
| _version_ | 1811078998293217280 |
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| author | Lundqvist, Mikael Rose, Jonas Brincat, Scott L Warden, Melissa R Buschman, Timothy J Herman, Pawel Miller, Earl K |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Lundqvist, Mikael Rose, Jonas Brincat, Scott L Warden, Melissa R Buschman, Timothy J Herman, Pawel Miller, Earl K |
| author_sort | Lundqvist, Mikael |
| collection | MIT |
| description | <jats:title>Abstract</jats:title><jats:p>Working memories have long been thought to be maintained by persistent spiking. However, mounting evidence from multiple-electrode recording (and single-trial analyses) shows that the underlying spiking is better characterized by intermittent bursts of activity. A counterargument suggested this intermittent activity is at odds with observations that spike-time variability reduces during task performance. However, this counterargument rests on assumptions, such as randomness in the timing of the bursts, which may not be correct. Thus, we analyzed spiking and LFPs from monkeys’ prefrontal cortex (PFC) to determine if task-related reductions in variability can co-exist with intermittent spiking. We found that it does because both spiking and associated gamma bursts were task-modulated, not random. In fact, the task-related reduction in spike variability could largely be explained by a related reduction in gamma burst variability. Our results provide further support for the intermittent activity models of working memory as well as novel mechanistic insights into how spike variability is reduced during cognitive tasks.</jats:p> |
| first_indexed | 2024-09-23T11:08:33Z |
| format | Article |
| id | mit-1721.1/150019 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:08:33Z |
| publishDate | 2023 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/1500192023-04-01T03:41:24Z Reduced variability of bursting activity during working memory Lundqvist, Mikael Rose, Jonas Brincat, Scott L Warden, Melissa R Buschman, Timothy J Herman, Pawel Miller, Earl K Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences <jats:title>Abstract</jats:title><jats:p>Working memories have long been thought to be maintained by persistent spiking. However, mounting evidence from multiple-electrode recording (and single-trial analyses) shows that the underlying spiking is better characterized by intermittent bursts of activity. A counterargument suggested this intermittent activity is at odds with observations that spike-time variability reduces during task performance. However, this counterargument rests on assumptions, such as randomness in the timing of the bursts, which may not be correct. Thus, we analyzed spiking and LFPs from monkeys’ prefrontal cortex (PFC) to determine if task-related reductions in variability can co-exist with intermittent spiking. We found that it does because both spiking and associated gamma bursts were task-modulated, not random. In fact, the task-related reduction in spike variability could largely be explained by a related reduction in gamma burst variability. Our results provide further support for the intermittent activity models of working memory as well as novel mechanistic insights into how spike variability is reduced during cognitive tasks.</jats:p> 2023-03-30T17:13:01Z 2023-03-30T17:13:01Z 2022 2023-03-30T17:01:36Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/150019 Lundqvist, Mikael, Rose, Jonas, Brincat, Scott L, Warden, Melissa R, Buschman, Timothy J et al. 2022. "Reduced variability of bursting activity during working memory." Scientific Reports, 12 (1). en 10.1038/S41598-022-18577-Y Scientific Reports Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Springer Science and Business Media LLC Scientific Reports |
| spellingShingle | Lundqvist, Mikael Rose, Jonas Brincat, Scott L Warden, Melissa R Buschman, Timothy J Herman, Pawel Miller, Earl K Reduced variability of bursting activity during working memory |
| title | Reduced variability of bursting activity during working memory |
| title_full | Reduced variability of bursting activity during working memory |
| title_fullStr | Reduced variability of bursting activity during working memory |
| title_full_unstemmed | Reduced variability of bursting activity during working memory |
| title_short | Reduced variability of bursting activity during working memory |
| title_sort | reduced variability of bursting activity during working memory |
| url | https://hdl.handle.net/1721.1/150019 |
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