Beyond dimension reduction: Stable electric fields emerge from and allow representational drift
It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric field...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2023
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| Online Access: | https://hdl.handle.net/1721.1/150021 |
| _version_ | 1826188275890520064 |
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| author | Pinotsis, Dimitris A Miller, Earl K |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Pinotsis, Dimitris A Miller, Earl K |
| author_sort | Pinotsis, Dimitris A |
| collection | MIT |
| description | It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory. |
| first_indexed | 2024-09-23T07:57:11Z |
| format | Article |
| id | mit-1721.1/150021 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T07:57:11Z |
| publishDate | 2023 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1500212023-04-01T04:07:16Z Beyond dimension reduction: Stable electric fields emerge from and allow representational drift Pinotsis, Dimitris A Miller, Earl K Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as "guard rails" that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory. 2023-03-30T17:20:20Z 2023-03-30T17:20:20Z 2022 2023-03-30T17:15:58Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/150021 Pinotsis, Dimitris A and Miller, Earl K. 2022. "Beyond dimension reduction: Stable electric fields emerge from and allow representational drift." NeuroImage, 253. en 10.1016/J.NEUROIMAGE.2022.119058 NeuroImage Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV Elsevier |
| spellingShingle | Pinotsis, Dimitris A Miller, Earl K Beyond dimension reduction: Stable electric fields emerge from and allow representational drift |
| title | Beyond dimension reduction: Stable electric fields emerge from and allow representational drift |
| title_full | Beyond dimension reduction: Stable electric fields emerge from and allow representational drift |
| title_fullStr | Beyond dimension reduction: Stable electric fields emerge from and allow representational drift |
| title_full_unstemmed | Beyond dimension reduction: Stable electric fields emerge from and allow representational drift |
| title_short | Beyond dimension reduction: Stable electric fields emerge from and allow representational drift |
| title_sort | beyond dimension reduction stable electric fields emerge from and allow representational drift |
| url | https://hdl.handle.net/1721.1/150021 |
| work_keys_str_mv | AT pinotsisdimitrisa beyonddimensionreductionstableelectricfieldsemergefromandallowrepresentationaldrift AT millerearlk beyonddimensionreductionstableelectricfieldsemergefromandallowrepresentationaldrift |