Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer’s disease mouse models

Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer’s disease mouse models

<jats:title>Abstract</jats:title><jats:p>Microglia and complement can mediate neurodegeneration in Alzheimer’s disease (AD). By integrative multi-omics analysis, here we show that astrocytic and microglial proteins are increased in Tau<jats:sup>P301S</jats:sup> synapse...

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Bibliographic Details
Main Authors: Dejanovic, Borislav, Wu, Tiffany, Tsai, Ming-Chi, Graykowski, David, Gandham, Vineela D, Rose, Christopher M, Bakalarski, Corey E, Ngu, Hai, Wang, Yuanyuan, Pandey, Shristi, Rezzonico, Mitchell G, Friedman, Brad A, Edmonds, Rose, De Mazière, Ann, Rakosi-Schmidt, Raphael, Singh, Tarjinder, Klumperman, Judith, Foreman, Oded, Chang, Michael C, Xie, Luke, Sheng, Morgan, Hanson, Jesse E
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2023
Online Access:https://hdl.handle.net/1721.1/150029

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