The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration

The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration

<jats:p>Complement overactivation mediates microglial synapse elimination in neurological diseases such as Alzheimer’s disease (AD) and frontotemporal dementia (FTD), but how complement activity is regulated in the brain remains largely unknown. We identified that the secreted neuronal pentrax...

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Detalhes bibliográficos
Principais autores: Zhou, Jiechao, Wade, Sarah D, Graykowski, David, Xiao, Mei-Fang, Zhao, Binhui, Giannini, Lucia AA, Hanson, Jesse E, van Swieten, John C, Sheng, Morgan, Worley, Paul F, Dejanovic, Borislav
Outros Autores: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Formato: Artigo
Idioma:English
Publicado em: American Association for the Advancement of Science (AAAS) 2023
Acesso em linha:https://hdl.handle.net/1721.1/150035

Internet

https://hdl.handle.net/1721.1/150035

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