The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration

The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration

<jats:p>Complement overactivation mediates microglial synapse elimination in neurological diseases such as Alzheimer’s disease (AD) and frontotemporal dementia (FTD), but how complement activity is regulated in the brain remains largely unknown. We identified that the secreted neuronal pentrax...

Full description

Bibliographic Details
Main Authors: Zhou, Jiechao, Wade, Sarah D, Graykowski, David, Xiao, Mei-Fang, Zhao, Binhui, Giannini, Lucia AA, Hanson, Jesse E, van Swieten, John C, Sheng, Morgan, Worley, Paul F, Dejanovic, Borislav
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2023
Online Access:https://hdl.handle.net/1721.1/150035

Similar Items

Similar Items