Mechanism and Biological Scope of Target-Directed MicroRNA Degradation
MicroRNAs (miRNAs) are small, ~21 nucleotide RNAs that guide Argonaute (AGO) proteins to complementary target RNAs using base-pairing interactions. In canonical miRNA-mediated repression, AGO recruits repressive trans-acting factors to bound targets to promote their deadenylation, decapping, and sub...
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| Format: | Thesis |
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Massachusetts Institute of Technology
2023
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| Online Access: | https://hdl.handle.net/1721.1/150110 |