HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity

HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity

Abstract Background Nef performs multiple cellular activities that enhance HIV-1 pathogenesis. The role of Nef-mediated down-regulation of the host restriction factor SERINC5 in HIV-1 pathogenesis is not well-defined. We aimed to investigate if SERIN...

Full description

Bibliographic Details
Main Authors:	Naicker, Delon, Sonela, Nelson, Jin, Steven W., Mulaudzi, Takalani, Ojwach, Doty, Reddy, Tarylee, Brockman, Mark A., Brumme, Zabrina L., Ndung’u, Thumbi, Mann, Jaclyn K.
Other Authors:	Ragon Institute of MGH, MIT and Harvard
Format:	Article
Language:	English
Published:	BioMed Central 2023
Online Access:	https://hdl.handle.net/1721.1/150334

Similar Items

HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity
by: Delon Naicker, et al.
Published: (2023-03-01)

Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5.
by: Steven W Jin, et al.
Published: (2020-09-01)

Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity
by: Steven W. Jin, et al.
Published: (2019-11-01)

Potent Enhancement of HIV-1 Replication by Nef in the Absence of SERINC3 and SERINC5
by: Yuanfei Wu, et al.
Published: (2019-06-01)

Spotlight on HIV-1 Nef: SERINC3 and SERINC5 Identified as Restriction Factors Antagonized by the Pathogenesis Factor
by: Oliver T. Fackler
Published: (2015-12-01)

Modelling and in vitro testing of the HIV-1 Nef fitness landscape
by: Barton, John P, et al.
Published: (2021)

AP-2 Adaptor Complex-Dependent Enhancement of HIV-1 Replication by Nef in the Absence of the Nef/AP-2 Targets SERINC5 and CD4
by: Balaji Olety, et al.
Published: (2023-02-01)

Nef Obtained from Individuals with HIV-1 Vary in Their Ability to Antagonize SERINC3- and SERINC5-Mediated HIV-1 Restriction
by: Zita Kruize, et al.
Published: (2021-03-01)

Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes.
by: Mann, J, et al.
Published: (2013)

Attenuated HIV-1 Nef But Not Vpu Function in a Cohort of Rwandan Long-Term Survivors
by: Gisele Umviligihozo, et al.
Published: (2022-06-01)

Attenuation of multiple Nef functions in HIV-1 elite controllers
by: Mwimanzi Philip, et al.
Published: (2013-01-01)

Impairment of viral replication capacity by <it>nef</it> alleles from HIV elite controllers
by: Walker Bruce, et al.
Published: (2011-10-01)

HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins
by: Brumme, Zabrina L., et al.
Published: (2010)

HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins.
by: Zabrina L Brumme, et al.
Published: (2009-08-01)

HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity
by: Qingqing Chai, et al.
Published: (2021-08-01)

A Long Cytoplasmic Loop Governs the Sensitivity of the Anti-viral Host Protein SERINC5 to HIV-1 Nef
by: Weiwei Dai, et al.
Published: (2018-01-01)

Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences
by: Macdonald Mahiti, et al.
Published: (2016-03-01)

Limited Sequence Variation and Similar Phenotypic Characteristics of HIV-1 Subtype C Gag Variants Derived From the Reservoir and Pre-Therapy Plasma
by: Doty Ojwach, et al.
Published: (2022-07-01)

Nef genotype influences immune control in individuals living with HIV-1 who carrying protective alleles
by: F. Method Mwimanzi, et al.
Published: (2019-07-01)

A Conserved Acidic Residue in the C-Terminal Flexible Loop of HIV-1 Nef Contributes to the Activity of SERINC5 and CD4 Downregulation
by: Claudia Firrito, et al.
Published: (2023-02-01)

Kelam’da Nefs Fenomenolojisi
by: Tuğba Günal
Published: (2022-06-01)

HIV-1 Nef: at the crossroads
by: Garcia J Victor, et al.
Published: (2008-09-01)

Nef and HIV/SIV Replication
by: Peterlin Matija
Published: (2005-12-01)

Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef's functionality in primary macrophages
by: Suzu Shinya, et al.
Published: (2011-06-01)

Integration site-independent enhancement of latency reversal by HIV-1 Nef
by: X.T. Kuang, et al.
Published: (2017-12-01)

P09-10. Impact of CTL escape mutations in HIV-1 Nef on viral replication
by: Altfeld M, et al.
Published: (2009-10-01)

Ölümünün 350. yılında Nef'i
by: Tulga Ocak
Published: (1985-12-01)

The Nef activity on HIV-1 infectivity
by: Stéphane eBasmaciogullari, et al.
Published: (2014-05-01)

Down-regulation of CTLA-4 by HIV-1 Nef protein.
by: Mohamed El-Far, et al.
Published: (2013-01-01)

SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue.
by: Dorota Kmiec, et al.
Published: (2018-08-01)

The role of Nef protein in the pathogenesis of HIV infection
by: Rajapaksa, U
Published: (2013)

Ramified cover of varieties with nef cotangent bundle
by: Wang, Yiyu
Published: (2022-09-01)

Strictly nef vector bundles and characterizations of ℙn
by: Liu Jie, et al.
Published: (2021-03-01)

TNF and HIV-1 Nef: An Intimate Interplay
by: Georges Herbein
Published: (2016-11-01)

Nefness of adjoint bundles for ample vector bundles
by: Hidetoshi Maeda
Published: (1995-11-01)

Threefolds with big and nef anticanonical bundles II
by: Jahnke Priska, et al.
Published: (2011-06-01)

Genetic defects in the nef gene are associated with Korean Red Ginseng intake: monitoring of nef sequence polymorphisms over 20 years
by: Young-Keol Cho, et al.
Published: (2017-04-01)

Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction
by: Sunan Li, et al.
Published: (2022-04-01)

HIV-1 down-regulates the expression of CD1d via Nef.
by: Chen, N, et al.
Published: (2006)

Nef cones of fiber products and an application to the cone conjecture
by: Cécile Gachet, et al.
Published: (2024-01-01)