HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity

HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity

Abstract Background Nef performs multiple cellular activities that enhance HIV-1 pathogenesis. The role of Nef-mediated down-regulation of the host restriction factor SERINC5 in HIV-1 pathogenesis is not well-defined. We aimed to investigate if SERIN...

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Bibliographic Details
Main Authors: Naicker, Delon, Sonela, Nelson, Jin, Steven W., Mulaudzi, Takalani, Ojwach, Doty, Reddy, Tarylee, Brockman, Mark A., Brumme, Zabrina L., Ndung’u, Thumbi, Mann, Jaclyn K.
Other Authors: Ragon Institute of MGH, MIT and Harvard
Format: Article
Language:English
Published: BioMed Central 2023
Online Access:https://hdl.handle.net/1721.1/150334

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