Structure of the IscB–ωRNA ribonucleoprotein complex, the likely ancestor of CRISPR-Cas9

Structure of the IscB–ωRNA ribonucleoprotein complex, the likely ancestor of CRISPR-Cas9

<jats:title>Abstract</jats:title><jats:p>Transposon-encoded IscB family proteins are RNA-guided nucleases in the OMEGA (obligate mobile element-guided activity) system, and likely ancestors of the RNA-guided nuclease Cas9 in the type II CRISPR-Cas adaptive immune system. IscB assoc...

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Bibliographic Details
Main Authors: Kato, Kazuki, Okazaki, Sae, Kannan, Soumya, Altae-Tran, Han, Esra Demircioglu, F, Isayama, Yukari, Ishikawa, Junichiro, Fukuda, Masahiro, Macrae, Rhiannon K, Nishizawa, Tomohiro, Makarova, Kira S, Koonin, Eugene V, Zhang, Feng, Nishimasu, Hiroshi
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2023
Online Access:https://hdl.handle.net/1721.1/150366

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