Dynamic control of visually guided locomotion through corticosubthalamic projections
Goal-directed locomotion requires control signals that propagate from higher order areas to regulate spinal mechanisms. The corticosubthalamic hyperdirect pathway offers a short route for cortical information to reach locomotor centers in the brainstem. We developed a task in which head-fixed mice r...
| Príomhchruthaitheoirí: | , , |
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| Formáid: | Alt |
| Teanga: | English |
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Elsevier BV
2023
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| Rochtain ar líne: | https://hdl.handle.net/1721.1/150372 |
| _version_ | 1826202437452562432 |
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| author | Adam, Elie M Johns, Taylor Sur, Mriganka |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Adam, Elie M Johns, Taylor Sur, Mriganka |
| author_sort | Adam, Elie M |
| collection | MIT |
| description | Goal-directed locomotion requires control signals that propagate from higher order areas to regulate spinal mechanisms. The corticosubthalamic hyperdirect pathway offers a short route for cortical information to reach locomotor centers in the brainstem. We developed a task in which head-fixed mice run to a visual landmark and then stop and wait to collect the reward and examined the role of secondary motor cortex (M2) projections to the subthalamic nucleus (STN) in controlling locomotion. Our behavioral modeling, calcium imaging, and optogenetics manipulation results suggest that the M2-STN pathway can be recruited during visually guided locomotion to rapidly and precisely control the pedunculopontine nucleus (PPN) of the mesencephalic locomotor region through the basal ganglia. By capturing the physiological dynamics through a feedback control model and analyzing neuronal signals in M2, PPN, and STN, we find that the corticosubthalamic projections potentially control PPN activity by differentiating an M2 error signal to ensure fast input-output dynamics. |
| first_indexed | 2024-09-23T12:07:27Z |
| format | Article |
| id | mit-1721.1/150372 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T12:07:27Z |
| publishDate | 2023 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1503722023-04-05T03:29:54Z Dynamic control of visually guided locomotion through corticosubthalamic projections Adam, Elie M Johns, Taylor Sur, Mriganka Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Goal-directed locomotion requires control signals that propagate from higher order areas to regulate spinal mechanisms. The corticosubthalamic hyperdirect pathway offers a short route for cortical information to reach locomotor centers in the brainstem. We developed a task in which head-fixed mice run to a visual landmark and then stop and wait to collect the reward and examined the role of secondary motor cortex (M2) projections to the subthalamic nucleus (STN) in controlling locomotion. Our behavioral modeling, calcium imaging, and optogenetics manipulation results suggest that the M2-STN pathway can be recruited during visually guided locomotion to rapidly and precisely control the pedunculopontine nucleus (PPN) of the mesencephalic locomotor region through the basal ganglia. By capturing the physiological dynamics through a feedback control model and analyzing neuronal signals in M2, PPN, and STN, we find that the corticosubthalamic projections potentially control PPN activity by differentiating an M2 error signal to ensure fast input-output dynamics. 2023-04-04T12:36:30Z 2023-04-04T12:36:30Z 2022 2023-04-04T12:00:36Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/150372 Adam, Elie M, Johns, Taylor and Sur, Mriganka. 2022. "Dynamic control of visually guided locomotion through corticosubthalamic projections." Cell Reports, 40 (4). en 10.1016/J.CELREP.2022.111139 Cell Reports Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV Elsevier |
| spellingShingle | Adam, Elie M Johns, Taylor Sur, Mriganka Dynamic control of visually guided locomotion through corticosubthalamic projections |
| title | Dynamic control of visually guided locomotion through corticosubthalamic projections |
| title_full | Dynamic control of visually guided locomotion through corticosubthalamic projections |
| title_fullStr | Dynamic control of visually guided locomotion through corticosubthalamic projections |
| title_full_unstemmed | Dynamic control of visually guided locomotion through corticosubthalamic projections |
| title_short | Dynamic control of visually guided locomotion through corticosubthalamic projections |
| title_sort | dynamic control of visually guided locomotion through corticosubthalamic projections |
| url | https://hdl.handle.net/1721.1/150372 |
| work_keys_str_mv | AT adameliem dynamiccontrolofvisuallyguidedlocomotionthroughcorticosubthalamicprojections AT johnstaylor dynamiccontrolofvisuallyguidedlocomotionthroughcorticosubthalamicprojections AT surmriganka dynamiccontrolofvisuallyguidedlocomotionthroughcorticosubthalamicprojections |