Somatosensory cortical signature of facial nociception and vibrotactile touch–induced analgesia
<jats:p>Pain relief by vibrotactile touch is a common human experience. Previous neurophysiological investigations of its underlying mechanism in animals focused on spinal circuits, while human studies suggested the involvement of supraspinal pathways. Here, we examine the role of primary soma...
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2023
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| Online Access: | https://hdl.handle.net/1721.1/150383 |
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| author | Lu, Jinghao Chen, Bin Levy, Manuel Xu, Peng Han, Bao-Xia Takatoh, Jun Thompson, PM He, Zhigang Prevosto, Vincent Wang, Fan |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Lu, Jinghao Chen, Bin Levy, Manuel Xu, Peng Han, Bao-Xia Takatoh, Jun Thompson, PM He, Zhigang Prevosto, Vincent Wang, Fan |
| author_sort | Lu, Jinghao |
| collection | MIT |
| description | <jats:p>Pain relief by vibrotactile touch is a common human experience. Previous neurophysiological investigations of its underlying mechanism in animals focused on spinal circuits, while human studies suggested the involvement of supraspinal pathways. Here, we examine the role of primary somatosensory cortex (S1) in touch-induced mechanical and heat analgesia. We found that, in mice, vibrotactile reafferent signals from self-generated whisking significantly reduce facial nociception, which is abolished by specifically blocking touch transmission from thalamus to the barrel cortex (S1B). Using a signal separation algorithm that can decompose calcium signals into sensory-evoked, whisking, or face-wiping responses, we found that the presence of whisking altered nociceptive signal processing in S1B neurons. Analysis of S1B population dynamics revealed that whisking pushes the transition of the neural state induced by noxious stimuli toward the outcome of non-nocifensive actions. Thus, S1B integrates facial tactile and noxious signals to enable touch-mediated analgesia.</jats:p> |
| first_indexed | 2024-09-23T14:47:00Z |
| format | Article |
| id | mit-1721.1/150383 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T14:47:00Z |
| publishDate | 2023 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/1503832023-04-05T03:14:25Z Somatosensory cortical signature of facial nociception and vibrotactile touch–induced analgesia Lu, Jinghao Chen, Bin Levy, Manuel Xu, Peng Han, Bao-Xia Takatoh, Jun Thompson, PM He, Zhigang Prevosto, Vincent Wang, Fan Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences <jats:p>Pain relief by vibrotactile touch is a common human experience. Previous neurophysiological investigations of its underlying mechanism in animals focused on spinal circuits, while human studies suggested the involvement of supraspinal pathways. Here, we examine the role of primary somatosensory cortex (S1) in touch-induced mechanical and heat analgesia. We found that, in mice, vibrotactile reafferent signals from self-generated whisking significantly reduce facial nociception, which is abolished by specifically blocking touch transmission from thalamus to the barrel cortex (S1B). Using a signal separation algorithm that can decompose calcium signals into sensory-evoked, whisking, or face-wiping responses, we found that the presence of whisking altered nociceptive signal processing in S1B neurons. Analysis of S1B population dynamics revealed that whisking pushes the transition of the neural state induced by noxious stimuli toward the outcome of non-nocifensive actions. Thus, S1B integrates facial tactile and noxious signals to enable touch-mediated analgesia.</jats:p> 2023-04-04T14:58:53Z 2023-04-04T14:58:53Z 2022-11-18 2023-04-04T14:46:39Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/150383 Lu, Jinghao, Chen, Bin, Levy, Manuel, Xu, Peng, Han, Bao-Xia et al. 2022. "Somatosensory cortical signature of facial nociception and vibrotactile touch–induced analgesia." Science Advances, 8 (46). en 10.1126/sciadv.abn6530 Science Advances Creative Commons Attribution NonCommercial License 4.0 https://creativecommons.org/licenses/by-nc/4.0/ application/pdf American Association for the Advancement of Science (AAAS) Science Advances |
| spellingShingle | Lu, Jinghao Chen, Bin Levy, Manuel Xu, Peng Han, Bao-Xia Takatoh, Jun Thompson, PM He, Zhigang Prevosto, Vincent Wang, Fan Somatosensory cortical signature of facial nociception and vibrotactile touch–induced analgesia |
| title | Somatosensory cortical signature of facial nociception and vibrotactile touch–induced analgesia |
| title_full | Somatosensory cortical signature of facial nociception and vibrotactile touch–induced analgesia |
| title_fullStr | Somatosensory cortical signature of facial nociception and vibrotactile touch–induced analgesia |
| title_full_unstemmed | Somatosensory cortical signature of facial nociception and vibrotactile touch–induced analgesia |
| title_short | Somatosensory cortical signature of facial nociception and vibrotactile touch–induced analgesia |
| title_sort | somatosensory cortical signature of facial nociception and vibrotactile touch induced analgesia |
| url | https://hdl.handle.net/1721.1/150383 |
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