Human pathogenic RNA viruses establish noncompeting lineages by occupying independent niches
<jats:title>Significance</jats:title> <jats:p>Numerous pathogenic viruses are endemic in humans and cause a broad variety of diseases, but what is their potential for causing new pandemics? We show that most human pathogenic RNA viruses form multiple, cocirculating linea...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Proceedings of the National Academy of Sciences
2023
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| Online Access: | https://hdl.handle.net/1721.1/150403 |
| _version_ | 1826207929525600256 |
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| author | Mutz, Pascal Rochman, Nash D Wolf, Yuri I Faure, Guilhem Zhang, Feng Koonin, Eugene V |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Mutz, Pascal Rochman, Nash D Wolf, Yuri I Faure, Guilhem Zhang, Feng Koonin, Eugene V |
| author_sort | Mutz, Pascal |
| collection | MIT |
| description | <jats:title>Significance</jats:title>
<jats:p>Numerous pathogenic viruses are endemic in humans and cause a broad variety of diseases, but what is their potential for causing new pandemics? We show that most human pathogenic RNA viruses form multiple, cocirculating lineages with low turnover rates. These lineages appear to be largely noncompeting and occupy distinct epidemiological niches that are not regionally or seasonally defined, and their persistence appears to stem from limited outbreaks in small communities so that only a small fraction of the global susceptible population is infected at any time. However, due to globalization, interaction and competition between lineages might increase, potentially leading to increased diversification and pathogenicity. Thus, endemic viruses appear to merit global attention with respect to the prevention of future pandemics.</jats:p> |
| first_indexed | 2024-09-23T13:57:11Z |
| format | Article |
| id | mit-1721.1/150403 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T13:57:11Z |
| publishDate | 2023 |
| publisher | Proceedings of the National Academy of Sciences |
| record_format | dspace |
| spelling | mit-1721.1/1504032023-04-05T03:22:14Z Human pathogenic RNA viruses establish noncompeting lineages by occupying independent niches Mutz, Pascal Rochman, Nash D Wolf, Yuri I Faure, Guilhem Zhang, Feng Koonin, Eugene V Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences <jats:title>Significance</jats:title> <jats:p>Numerous pathogenic viruses are endemic in humans and cause a broad variety of diseases, but what is their potential for causing new pandemics? We show that most human pathogenic RNA viruses form multiple, cocirculating lineages with low turnover rates. These lineages appear to be largely noncompeting and occupy distinct epidemiological niches that are not regionally or seasonally defined, and their persistence appears to stem from limited outbreaks in small communities so that only a small fraction of the global susceptible population is infected at any time. However, due to globalization, interaction and competition between lineages might increase, potentially leading to increased diversification and pathogenicity. Thus, endemic viruses appear to merit global attention with respect to the prevention of future pandemics.</jats:p> 2023-04-04T17:01:28Z 2023-04-04T17:01:28Z 2022-06-07 2023-04-04T16:58:52Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/150403 Mutz, Pascal, Rochman, Nash D, Wolf, Yuri I, Faure, Guilhem, Zhang, Feng et al. 2022. "Human pathogenic RNA viruses establish noncompeting lineages by occupying independent niches." Proceedings of the National Academy of Sciences, 119 (23). en 10.1073/pnas.2121335119 Proceedings of the National Academy of Sciences Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/ application/pdf Proceedings of the National Academy of Sciences PNAS |
| spellingShingle | Mutz, Pascal Rochman, Nash D Wolf, Yuri I Faure, Guilhem Zhang, Feng Koonin, Eugene V Human pathogenic RNA viruses establish noncompeting lineages by occupying independent niches |
| title | Human pathogenic RNA viruses establish noncompeting lineages by occupying independent niches |
| title_full | Human pathogenic RNA viruses establish noncompeting lineages by occupying independent niches |
| title_fullStr | Human pathogenic RNA viruses establish noncompeting lineages by occupying independent niches |
| title_full_unstemmed | Human pathogenic RNA viruses establish noncompeting lineages by occupying independent niches |
| title_short | Human pathogenic RNA viruses establish noncompeting lineages by occupying independent niches |
| title_sort | human pathogenic rna viruses establish noncompeting lineages by occupying independent niches |
| url | https://hdl.handle.net/1721.1/150403 |
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