Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape
<jats:p>Emergence of vaccine escape variants of SARS-CoV-2 is arguably the most pressing problem during the COVID-19 pandemic as vaccines are distributed worldwide. We employed a computational approach to assess the risk of antibody escape resulting from mutations in the receptor-binding domai...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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American Society for Microbiology
2023
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| Online Access: | https://hdl.handle.net/1721.1/150406 |
| _version_ | 1826197557083111424 |
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| author | Rochman, Nash D Faure, Guilhem Wolf, Yuri I Freddolino, Peter L Zhang, Feng Koonin, Eugene V |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Rochman, Nash D Faure, Guilhem Wolf, Yuri I Freddolino, Peter L Zhang, Feng Koonin, Eugene V |
| author_sort | Rochman, Nash D |
| collection | MIT |
| description | <jats:p>Emergence of vaccine escape variants of SARS-CoV-2 is arguably the most pressing problem during the COVID-19 pandemic as vaccines are distributed worldwide. We employed a computational approach to assess the risk of antibody escape resulting from mutations in the receptor-binding domain of the spike protein of the wild-type SARS-CoV-2 virus as well as the Delta, Gamma, and Omicron variants.</jats:p> |
| first_indexed | 2024-09-23T10:49:29Z |
| format | Article |
| id | mit-1721.1/150406 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T10:49:29Z |
| publishDate | 2023 |
| publisher | American Society for Microbiology |
| record_format | dspace |
| spelling | mit-1721.1/1504062023-04-05T03:37:55Z Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape Rochman, Nash D Faure, Guilhem Wolf, Yuri I Freddolino, Peter L Zhang, Feng Koonin, Eugene V Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences <jats:p>Emergence of vaccine escape variants of SARS-CoV-2 is arguably the most pressing problem during the COVID-19 pandemic as vaccines are distributed worldwide. We employed a computational approach to assess the risk of antibody escape resulting from mutations in the receptor-binding domain of the spike protein of the wild-type SARS-CoV-2 virus as well as the Delta, Gamma, and Omicron variants.</jats:p> 2023-04-04T17:19:38Z 2023-04-04T17:19:38Z 2022-04-26 2023-04-04T17:17:02Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/150406 Rochman, Nash D, Faure, Guilhem, Wolf, Yuri I, Freddolino, Peter L, Zhang, Feng et al. 2022. "Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape." mBio, 13 (2). en 10.1128/mbio.00135-22 mBio Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/ application/pdf American Society for Microbiology ASM |
| spellingShingle | Rochman, Nash D Faure, Guilhem Wolf, Yuri I Freddolino, Peter L Zhang, Feng Koonin, Eugene V Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape |
| title | Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape |
| title_full | Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape |
| title_fullStr | Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape |
| title_full_unstemmed | Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape |
| title_short | Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape |
| title_sort | epistasis at the sars cov 2 receptor binding domain interface and the propitiously boring implications for vaccine escape |
| url | https://hdl.handle.net/1721.1/150406 |
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