Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration

Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration

<jats:p>DNA double-strand breaks (DSBs) are linked to neurodegeneration and senescence. However, it is not clear how DSB-bearing neurons influence neuroinflammation associated with neurodegeneration. Here, we characterize DSB-bearing neurons from the CK-p25 mouse model of neurodegeneration usi...

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Bibliographic Details
Main Authors: Welch, Gwyneth M, Boix, Carles A, Schmauch, Eloi, Davila-Velderrain, Jose, Victor, Matheus B, Dileep, Vishnu, Bozzelli, P Lorenzo, Su, Qiao, Cheng, Jemmie D, Lee, Audrey, Leary, Noelle S, Pfenning, Andreas R, Kellis, Manolis, Tsai, Li-Huei
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2023
Online Access:https://hdl.handle.net/1721.1/150407

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