Telomerase reverse transcriptase preserves neuron survival and cognition in Alzheimer’s disease models

Telomerase reverse transcriptase preserves neuron survival and cognition in Alzheimer’s disease models

Amyloid-induced neurodegeneration plays a central role in Alzheimer's disease (AD) pathogenesis. Here, we show that telomerase reverse transcriptase (TERT) haploinsufficiency decreases BDNF and increases amyloid-β (Aβ) precursor in murine brain. Moreover, prior to disease onset, the TERT locus...

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Bibliographic Details
Main Authors: Shim, Hong Seok, Horner, James W, Wu, Chang-Jiun, Li, Jiexi, Lan, Zheng D, Jiang, Shan, Xu, Xueping, Hsu, Wen-Hao, Zal, Tomasz, Flores, Ivonne I, Deng, Pingna, Lin, Yuan-Ta, Tsai, Li-Huei, Wang, Y Alan, DePinho, Ronald A
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2023
Online Access:https://hdl.handle.net/1721.1/150409

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