APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes

APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes

APOE4 is the strongest genetic risk factor for Alzheimer's disease1-3. However, the effects of APOE4 on the human brain are not fully understood, limiting opportunities to develop targeted therapeutics for individuals carrying APOE4 and other risk factors for Alzheimer's disease4-8. Here,...

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Bibliographic Details
Main Authors: Blanchard, Joel W, Akay, Leyla Anne, Davila-Velderrain, Jose, von Maydell, Djuna, Mathys, Hansruedi, Davidson, Shawn M, Effenberger, Audrey, Chen, Chih-Yu, Maner-Smith, Kristal, Hajjar, Ihab, Ortlund, Eric A, Bula, Michael, Agbas, Emre, Ng, Ayesha, Jiang, Xueqiao, Kahn, Martin, Blanco-Duque, Cristina, Lavoie, Nicolas, Liu, Liwang, Reyes, Ricardo, Lin, Yuan-Ta, Ko, Tak, R’Bibo, Lea, Ralvenius, William T, Bennett, David A, Cam, Hugh P, Kellis, Manolis, Tsai, Li-Huei
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2023
Online Access:https://hdl.handle.net/1721.1/150414

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