Histone Deacetylases 1 and 2 in Memory Function
Histone deacetylases (HDACs) have been implicated in learning and memory, and their dysregulation has been linked to cognitive impairment in brain aging and neurodegenerative diseases. In this review, we focus on HDAC1 and HDAC2, highlighting recent progress on their roles in regulating brain functi...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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American Chemical Society (ACS)
2023
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| Online Access: | https://hdl.handle.net/1721.1/150472 |
| _version_ | 1826198815138381824 |
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| author | Pao, Ping-Chieh Tsai, Li-Huei |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Pao, Ping-Chieh Tsai, Li-Huei |
| author_sort | Pao, Ping-Chieh |
| collection | MIT |
| description | Histone deacetylases (HDACs) have been implicated in learning and memory, and their dysregulation has been linked to cognitive impairment in brain aging and neurodegenerative diseases. In this review, we focus on HDAC1 and HDAC2, highlighting recent progress on their roles in regulating brain function through distinct mechanisms, including gene repression and DNA repair pathways. Moreover, we discuss evidence demonstrating how HDAC1 and HDAC2 could be modulated and their potential as targets to combat memory deficits. |
| first_indexed | 2024-09-23T11:10:27Z |
| format | Article |
| id | mit-1721.1/150472 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:10:27Z |
| publishDate | 2023 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/1504722023-04-11T03:35:15Z Histone Deacetylases 1 and 2 in Memory Function Pao, Ping-Chieh Tsai, Li-Huei Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Histone deacetylases (HDACs) have been implicated in learning and memory, and their dysregulation has been linked to cognitive impairment in brain aging and neurodegenerative diseases. In this review, we focus on HDAC1 and HDAC2, highlighting recent progress on their roles in regulating brain function through distinct mechanisms, including gene repression and DNA repair pathways. Moreover, we discuss evidence demonstrating how HDAC1 and HDAC2 could be modulated and their potential as targets to combat memory deficits. 2023-04-10T13:46:53Z 2023-04-10T13:46:53Z 2022 2023-04-10T13:44:39Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/150472 Pao, Ping-Chieh and Tsai, Li-Huei. 2022. "Histone Deacetylases 1 and 2 in Memory Function." ACS Chemical Neuroscience, 13 (7). en 10.1021/ACSCHEMNEURO.1C00775 ACS Chemical Neuroscience Creative Commons Attribution-Noncommercial-Share Alike https://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Chemical Society (ACS) Tsai |
| spellingShingle | Pao, Ping-Chieh Tsai, Li-Huei Histone Deacetylases 1 and 2 in Memory Function |
| title | Histone Deacetylases 1 and 2 in Memory Function |
| title_full | Histone Deacetylases 1 and 2 in Memory Function |
| title_fullStr | Histone Deacetylases 1 and 2 in Memory Function |
| title_full_unstemmed | Histone Deacetylases 1 and 2 in Memory Function |
| title_short | Histone Deacetylases 1 and 2 in Memory Function |
| title_sort | histone deacetylases 1 and 2 in memory function |
| url | https://hdl.handle.net/1721.1/150472 |
| work_keys_str_mv | AT paopingchieh histonedeacetylases1and2inmemoryfunction AT tsailihuei histonedeacetylases1and2inmemoryfunction |