Insights into Alzheimer’s disease from single-cell genomic approaches
Alzheimer's disease (AD) is an age-related disease pathologically defined by the deposition of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling has shown that Alzheimer's dementia involves the complex interplay of virtually every major brain cell t...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Springer Science and Business Media LLC
2023
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| Online Access: | https://hdl.handle.net/1721.1/150474 |
| _version_ | 1811094973651615744 |
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| author | Murdock, Mitchell H Tsai, Li-Huei |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Murdock, Mitchell H Tsai, Li-Huei |
| author_sort | Murdock, Mitchell H |
| collection | MIT |
| description | Alzheimer's disease (AD) is an age-related disease pathologically defined by the deposition of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling has shown that Alzheimer's dementia involves the complex interplay of virtually every major brain cell type. Here, we highlight cell-type-specific molecular perturbations in AD. We discuss how genomic information from single cells expands existing paradigms of AD pathogenesis and highlight new opportunities for therapeutic interventions. |
| first_indexed | 2024-09-23T16:08:30Z |
| format | Article |
| id | mit-1721.1/150474 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:08:30Z |
| publishDate | 2023 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/1504742023-04-11T03:03:01Z Insights into Alzheimer’s disease from single-cell genomic approaches Murdock, Mitchell H Tsai, Li-Huei Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Alzheimer's disease (AD) is an age-related disease pathologically defined by the deposition of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling has shown that Alzheimer's dementia involves the complex interplay of virtually every major brain cell type. Here, we highlight cell-type-specific molecular perturbations in AD. We discuss how genomic information from single cells expands existing paradigms of AD pathogenesis and highlight new opportunities for therapeutic interventions. 2023-04-10T13:55:37Z 2023-04-10T13:55:37Z 2023-02 2023-04-10T13:53:20Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/150474 Murdock, Mitchell H and Tsai, Li-Huei. 2023. "Insights into Alzheimer’s disease from single-cell genomic approaches." Nature Neuroscience, 26 (2). en 10.1038/s41593-022-01222-2 Nature Neuroscience Creative Commons Attribution-Noncommercial-Share Alike https://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Springer Science and Business Media LLC Tsai |
| spellingShingle | Murdock, Mitchell H Tsai, Li-Huei Insights into Alzheimer’s disease from single-cell genomic approaches |
| title | Insights into Alzheimer’s disease from single-cell genomic approaches |
| title_full | Insights into Alzheimer’s disease from single-cell genomic approaches |
| title_fullStr | Insights into Alzheimer’s disease from single-cell genomic approaches |
| title_full_unstemmed | Insights into Alzheimer’s disease from single-cell genomic approaches |
| title_short | Insights into Alzheimer’s disease from single-cell genomic approaches |
| title_sort | insights into alzheimer s disease from single cell genomic approaches |
| url | https://hdl.handle.net/1721.1/150474 |
| work_keys_str_mv | AT murdockmitchellh insightsintoalzheimersdiseasefromsinglecellgenomicapproaches AT tsailihuei insightsintoalzheimersdiseasefromsinglecellgenomicapproaches |