Single-Particle Tracking of Thermomyces lanuginosus Lipase Reveals How Mutations in the Lid Region Remodel Its Diffusion

The function of most lipases is controlled by the lid, which undergoes conformational changes at a water–lipid interface to expose the active site, thus activating catalysis. Understanding how lid mutations affect lipases’ function is important for designing improved variants. Li...

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Bibliographic Details
Main Authors: Iversen, Josephine F., Bohr, Søren S.-R., Pinholt, Henrik D., Moses, Matias E., Iversen, Lars, Christensen, Sune M., Hatzakis, Nikos S., Zhang, Min
Other Authors: Massachusetts Institute of Technology. Department of Physics
Format: Article
Published: Multidisciplinary Digital Publishing Institute 2023
Online Access:https://hdl.handle.net/1721.1/150487