Mapping the Unseen: In Vivo CEST-MRI of Creatine Reveals Improved Cardiac Energetics in Subjects with Obesity Following Bariatric Surgery
Abstract Background Obesity is associated with derangement of cardiac metabolism and the development of subclinical cardiovascular disease. This prospective study examined the impact of bariatric surgery on cardiac function and metabolism....
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Springer US
2023
|
| Online Access: | https://hdl.handle.net/1721.1/150851 |
| _version_ | 1811092356349296640 |
|---|---|
| author | Yurista, Salva R. Chen, Shi Eder, Robert A. Garrett, Thomas Butsch, W. S. Aminian, Ali Tang, W. H. W. Farrar, Christian T. Gee, Denise Abel, E. D. Das, Saumya Nguyen, Christopher T. |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Yurista, Salva R. Chen, Shi Eder, Robert A. Garrett, Thomas Butsch, W. S. Aminian, Ali Tang, W. H. W. Farrar, Christian T. Gee, Denise Abel, E. D. Das, Saumya Nguyen, Christopher T. |
| author_sort | Yurista, Salva R. |
| collection | MIT |
| description | Abstract
Background
Obesity is associated with derangement of cardiac metabolism and the development of subclinical cardiovascular disease. This prospective study examined the impact of bariatric surgery on cardiac function and metabolism.
Methods
Subjects with obesity underwent cardiac magnetic resonance imaging (CMR) at Massachusetts General Hospital before and after bariatric surgery between 2019 and 2021. The imaging protocol included Cine for global cardiac function assessment and creatine chemical exchange saturation transfer (CEST) CMR for myocardial creatine mapping.
Results
Thirteen subjects were enrolled, and 6 subjects [mean BMI 40.5 ± 2.6] had completed the second CMR (i.e. post-surgery), with a median follow-up of 10 months. The median age was 46.5 years, 67% were female, and 16.67% had diabetes. Bariatric surgery led to significant weight loss, with achieved mean BMI of 31.0 ± 2.0. Additionally, bariatric surgery resulted in significant reduction in left ventricular (LV) mass, LV mass index, and epicardial adipose tissue (EAT) volume. This was accompanied by slight improvement in LV ejection fraction compared to baseline. Following bariatric surgery, there was a significant increase in creatine CEST contrast. Subjects with obesity had significantly lower CEST contrast compared to subjects with normal BMI (n = 10), but this contrast was normalized after the surgery, and statistically similar to non-obese cohort, indicating an improvement in myocardial energetics.
Conclusions
CEST-CMR has the ability to identify and characterize myocardial metabolism in vivo non-invasively. These results demonstrate that in addition to reducing BMI, bariatric surgery may favorably affect cardiac function and metabolism.
Graphical Abstract |
| first_indexed | 2024-09-23T15:16:55Z |
| format | Article |
| id | mit-1721.1/150851 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T15:16:55Z |
| publishDate | 2023 |
| publisher | Springer US |
| record_format | dspace |
| spelling | mit-1721.1/1508512024-09-17T04:39:25Z Mapping the Unseen: In Vivo CEST-MRI of Creatine Reveals Improved Cardiac Energetics in Subjects with Obesity Following Bariatric Surgery Yurista, Salva R. Chen, Shi Eder, Robert A. Garrett, Thomas Butsch, W. S. Aminian, Ali Tang, W. H. W. Farrar, Christian T. Gee, Denise Abel, E. D. Das, Saumya Nguyen, Christopher T. Harvard University--MIT Division of Health Sciences and Technology Abstract Background Obesity is associated with derangement of cardiac metabolism and the development of subclinical cardiovascular disease. This prospective study examined the impact of bariatric surgery on cardiac function and metabolism. Methods Subjects with obesity underwent cardiac magnetic resonance imaging (CMR) at Massachusetts General Hospital before and after bariatric surgery between 2019 and 2021. The imaging protocol included Cine for global cardiac function assessment and creatine chemical exchange saturation transfer (CEST) CMR for myocardial creatine mapping. Results Thirteen subjects were enrolled, and 6 subjects [mean BMI 40.5 ± 2.6] had completed the second CMR (i.e. post-surgery), with a median follow-up of 10 months. The median age was 46.5 years, 67% were female, and 16.67% had diabetes. Bariatric surgery led to significant weight loss, with achieved mean BMI of 31.0 ± 2.0. Additionally, bariatric surgery resulted in significant reduction in left ventricular (LV) mass, LV mass index, and epicardial adipose tissue (EAT) volume. This was accompanied by slight improvement in LV ejection fraction compared to baseline. Following bariatric surgery, there was a significant increase in creatine CEST contrast. Subjects with obesity had significantly lower CEST contrast compared to subjects with normal BMI (n = 10), but this contrast was normalized after the surgery, and statistically similar to non-obese cohort, indicating an improvement in myocardial energetics. Conclusions CEST-CMR has the ability to identify and characterize myocardial metabolism in vivo non-invasively. These results demonstrate that in addition to reducing BMI, bariatric surgery may favorably affect cardiac function and metabolism. Graphical Abstract 2023-06-02T14:34:08Z 2023-06-02T14:34:08Z 2023-04-14 2023-06-02T03:19:39Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/150851 Yurista, Salva R., Chen, Shi, Eder, Robert A., Garrett, Thomas, Butsch, W. S. et al. 2023. "Mapping the Unseen: In Vivo CEST-MRI of Creatine Reveals Improved Cardiac Energetics in Subjects with Obesity Following Bariatric Surgery." en https://doi.org/10.1007/s11695-023-06589-0 Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature application/pdf Springer US Springer US |
| spellingShingle | Yurista, Salva R. Chen, Shi Eder, Robert A. Garrett, Thomas Butsch, W. S. Aminian, Ali Tang, W. H. W. Farrar, Christian T. Gee, Denise Abel, E. D. Das, Saumya Nguyen, Christopher T. Mapping the Unseen: In Vivo CEST-MRI of Creatine Reveals Improved Cardiac Energetics in Subjects with Obesity Following Bariatric Surgery |
| title | Mapping the Unseen: In Vivo CEST-MRI of Creatine Reveals Improved Cardiac Energetics in Subjects with Obesity Following Bariatric Surgery |
| title_full | Mapping the Unseen: In Vivo CEST-MRI of Creatine Reveals Improved Cardiac Energetics in Subjects with Obesity Following Bariatric Surgery |
| title_fullStr | Mapping the Unseen: In Vivo CEST-MRI of Creatine Reveals Improved Cardiac Energetics in Subjects with Obesity Following Bariatric Surgery |
| title_full_unstemmed | Mapping the Unseen: In Vivo CEST-MRI of Creatine Reveals Improved Cardiac Energetics in Subjects with Obesity Following Bariatric Surgery |
| title_short | Mapping the Unseen: In Vivo CEST-MRI of Creatine Reveals Improved Cardiac Energetics in Subjects with Obesity Following Bariatric Surgery |
| title_sort | mapping the unseen in vivo cest mri of creatine reveals improved cardiac energetics in subjects with obesity following bariatric surgery |
| url | https://hdl.handle.net/1721.1/150851 |
| work_keys_str_mv | AT yuristasalvar mappingtheunseeninvivocestmriofcreatinerevealsimprovedcardiacenergeticsinsubjectswithobesityfollowingbariatricsurgery AT chenshi mappingtheunseeninvivocestmriofcreatinerevealsimprovedcardiacenergeticsinsubjectswithobesityfollowingbariatricsurgery AT ederroberta mappingtheunseeninvivocestmriofcreatinerevealsimprovedcardiacenergeticsinsubjectswithobesityfollowingbariatricsurgery AT garrettthomas mappingtheunseeninvivocestmriofcreatinerevealsimprovedcardiacenergeticsinsubjectswithobesityfollowingbariatricsurgery AT butschws mappingtheunseeninvivocestmriofcreatinerevealsimprovedcardiacenergeticsinsubjectswithobesityfollowingbariatricsurgery AT aminianali mappingtheunseeninvivocestmriofcreatinerevealsimprovedcardiacenergeticsinsubjectswithobesityfollowingbariatricsurgery AT tangwhw mappingtheunseeninvivocestmriofcreatinerevealsimprovedcardiacenergeticsinsubjectswithobesityfollowingbariatricsurgery AT farrarchristiant mappingtheunseeninvivocestmriofcreatinerevealsimprovedcardiacenergeticsinsubjectswithobesityfollowingbariatricsurgery AT geedenise mappingtheunseeninvivocestmriofcreatinerevealsimprovedcardiacenergeticsinsubjectswithobesityfollowingbariatricsurgery AT abeled mappingtheunseeninvivocestmriofcreatinerevealsimprovedcardiacenergeticsinsubjectswithobesityfollowingbariatricsurgery AT dassaumya mappingtheunseeninvivocestmriofcreatinerevealsimprovedcardiacenergeticsinsubjectswithobesityfollowingbariatricsurgery AT nguyenchristophert mappingtheunseeninvivocestmriofcreatinerevealsimprovedcardiacenergeticsinsubjectswithobesityfollowingbariatricsurgery |